Obiettivo
The inflammatory bowel diseases (IBD) which comprise Crohn’s disease and ulcerative colitis are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract. The frequency of these conditions has increased in recent decades, particularly in countries making the transition from developing to developed nation status. In western Europe, IBD now affects between 1/1000 and 5/1000 of the population, and the prevalence of the conditions in new EU accession countries appears to be growing as they develop. Few conditions in all of clinical medicine are linked with as much morbidity and potential mortality as IBD. Current treatment is based upon steroid therapy or neutralizing the effect of pro-inflammatory cytokines, especially TNFalpha. Despite their efficacy, many patients eventually require surgery for refractory disease or complications (stricture, perforation, abscess). In response to the call we have assembled a multidisciplinary team of international experts to delineate the role of intestinal proteases and their inhibitors in the pathophysiology of IBD. A particularly innovative aspect of our approach is the examination of both bacterial and host derived proteases and interactions between the two. The ultimate aim is develop novel therapeutics and increased understanding of the disease both of which will impact within the wider EU community and globally.
Campo scientifico
Parole chiave
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2007-A
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research project
Coordinatore
S10 2TN Sheffield
United Kingdom
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Partecipanti (11)
E1 4NS London
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SO17 1BJ Southampton
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00133 Roma
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80333 Muenchen
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142 00 Praha 4
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1105AZ Amsterdam
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TW89GS Brentford
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T12 YN60 Cork
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N/A Cork
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1010 Auckland
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72074 Tuebingen
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