Skip to main content

Supramolecular Chemical Biology Modulation of Protein-Protein Interactions

Objective

This proposal aims to explore the combination of supramolecular chemistry with chemical biology. Supramolecular architectures are proposed for the modulation of protein-protein interactions. Two general themes are outlined; 1) supramolecular chemistry in the cell and 2) supramolecular multivalency. Supramolecular architectures are brought forward as excellent tools to control protein-protein interactions at the cellular level. Supramolecular elements, selectively attached to proteins, are outlined to control protein dimerization and localization. The introduction of different supramolecular elements, either in vitro or in vivo via specific labeling techniques, is part of the plan, including the introduction of supramolecular elements, whose interactions can be reversibly switched with light. With these systems, the temporal control over protein-protein interactions and protein localization can be addressed. Self-assembling multivalent architectures are proposed as optimal scaffolds and flexible systems for recognition and binding of cells. The assembly process of the supramolecular architecture will be steered via interplay with the characteristics of the cellular target and the environment, controlling size, shape and composition. This self-assembling multivalent platform will be applied to control or initiate interactions between different types of surfaces, such as cells, antigens and chips. The self-assembling scaffolds additionally provide an ideal platform to be combined with proteins, allowing the generation of ordered protein wires, with control over orientation and distances between proteins. The combination of supramolecular chemistry with chemical biology is envisioned to enable the modulation of protein-protein interactions and thus provide entries to this long standing fundamental challenge.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

ERC-2007-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

TECHNISCHE UNIVERSITEIT EINDHOVEN
Address
Groene Loper 3
5612 AE Eindhoven
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 250 000
Principal investigator
Lucas Brunsveld (Dr.)
Administrative Contact
Rob Debey (Mr.)

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 1 250 000
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
Principal investigator
Lucas Brunsveld (Dr.)
Administrative Contact
Rob Debey (Mr.)