Objective
Peroxisomes are organelles that have an essentially oxidative type of metabolism. In plant peroxisomes the presence of proteases and a set of antioxidative enzymes have been demonstrated. In addition, the presence of nitric oxide synthase suggests that they are a cellular source of NO and adds new cellular functions to peroxisomes related to oxygen and nitrogen reactive species as they have the capacity to generate and release into the cytosol important signal molecules. The study of the regulation of these molecules that could mediate the inter-organellar communication is an important emerging area in plant research, which can supply more information on peroxisomal contribution throughout plant development and in plant response to different stress condition. Recent evidences indicate that in animal tissues NO regulates diverse biologic processes by directly modifying proteins. NO and RNS can oxidize, nitrate or nitrosylate proteins. S-nitrosylation refers to the binding of a NO group to a cysteine residue and it could play a central role in NO-mediated signalling. Accumulating data suggest that many proteins are S-nitrosylated by NO indicating that S-nitrosylation may be a ubiquitous post-translational modification regulating protein function. It has been shown that S-nitrosylation plays a comparable role to phosphorylation in animal cell biology and signal transduction. However, very little is known about the dimension of the physiological function of S-nitrosylation in plants. The aim of the proposed project is to assess the occurrence of S-nitrosylation in plant peroxisomes, with the identification and functional characterization of the NO-target proteins. Additionally, we propose the study of the changes in the pattern of S-nitrosylated proteins during different stress conditions that will help us to understand the functional consequences and the relevance of S-nitrosylation and the role of peroxisomes in physiological and pathophysiological conditions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-2-ERG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.