Objective 90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients often suffer ‘unnecessary’ and painful infections following the formation of such films on surgical implants and catheters. With the growing problem of MRSA and C. difficile in hospitals, and the cost of policing and hygiene measures, an understanding of how to prevent bacterial persistence in the hospital environment is critical to the sustainability of European healthcare. A multi-disciplinary group of European experts have the common aim to understand exactly how bacteria attach to, and persist on both biological and inert surfaces. We will use a range of biological and physio-chemical techniques to study several fundamental aspects of bacterial attachment. We will employ new molecular microbiology techniques to understand the genetic components governing the interaction of a bacterial biotic cell surface with the novel antimicrobial surfaces we create. Second, we will be using new nano-scale material science and physical chemistry techniques to create and understand these antimicrobial surfaces. This duel systems approach will allow us to theoretically model the processes of bacterial attachment and survival, which in turn will allow us to improve these surfaces in an iterative approach. We will generate intellectual property around the coatings and treatments used to derive the surfaces and develop these in collaboration with industry. The solutions will be designed specifically for the industrial partners participating in the project but can, with a minimum effort be adapted for applications in other areas through the iterative steps within the WPs. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologyengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesmedical biotechnologyimplantsnatural scienceschemical sciencesphysical chemistry Keywords antimicrobial properties bio-analysis fundamental understanding in vivo models method validation polymers surface design Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-1.1-1 - Nano-scale mechanisms of bio/non-bio interactions Call for proposal FP7-NMP-2007-SMALL-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV EU contribution € 826 691,00 Address HOFGARTENSTRASSE 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Udo Schreiner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF BATH United Kingdom EU contribution € 731 400,00 Address CLAVERTON DOWN BA2 7AY Bath See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire Activity type Higher or Secondary Education Establishments Administrative Contact Peter Hompstead (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT Switzerland EU contribution € 381 000,00 Address UEBERLANDSTRASSE 129 8600 Dubendorf See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Dirk Hegemann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EXETER United Kingdom EU contribution € 357 000,00 Address THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Administrative Contact Enda Clarke (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 296 175,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Mar Garcia-Ferrer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITAET ZU KOELN Germany EU contribution € 322 200,00 Address Kerpener Strasse 62 50937 Koeln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jutta Landvogt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROCHE DIAGNOSTICS GMBH Germany EU contribution No data Address Sandhofer Strasse 116 68305 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christa Hübner-Parajsz (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NPL MANAGEMENT LIMITED United Kingdom EU contribution No data Address HAMPTON ROAD TEDDINGTON TW11 0LW Middlesex See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Neil Harrison (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SEFAR AG Switzerland EU contribution No data Address HINTERBISSAUSTRASSE 12 9410 HEIDEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Chabrecek (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Germany EU contribution No data Address Langenbeckstrasse 1 55131 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Silvia Tschauder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANNES GUTENBERG-UNIVERSITAT MAINZ Participation ended Germany EU contribution No data Address SAARSTRASSE 21 55122 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Petra Seebauer-Enste (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
