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Carbohydrate Multivalent Systems as tools to study Pathogen interaction with DC-SIGN

Objective

The importance of glycosciences in the development of biology and medicine and the central role played by chemistry in this process have recently been pointed out by ESF. However, it appears that exposure of young scientists in their training phase to the chemical biology of carbohydrates is still lacking. This multidisciplinary project intends to approach the design and synthesis of carbohydrate multivalent systems to be used as tools to study the interaction between carbohydrates and DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin), a C-type lectin implicated in the recognition of pathogens and in some of the earliest stages of the infection process. Targeting pathogens at the earliest stages of infection, before cell penetration, is of crucial importance because it can result in a significant decrease of pathogen titre in the organism and therefore will facilitate the efficiency of current therapies. The role that DC-SIGN plays in the immune response through the interaction and recognition of pathogens leads to a very complex pathway of signalling cascade that could be modulated using these carbohydrate multivalent systems as effectors. Thus the studies we propose could provide the background for the design, selection and preparation of better antiviral drugs and could afford new insights to unravel the complex mechanisms of the immune system, thus opening a strategy to develop vaccines through the modulation of dendritic cells activity. To reach these goals, a highly interdisciplinary group of scientists (synthetic chemists, computational chemists, biochemists, immunologists, etc.) has been assembled, some of whom are already collaborating on the topic. The planned flow of information between laboratories and the network-wide training activities described in this proposal will create an unrivalled environment for training of young scientists in glycosciences.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-PEOPLE-2007-1-1-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 512 344,76
Administrative Contact
Carlos Manuel Abad (Mr.)

Participants (12)

UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 408 247,38
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chiara Comin (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 213 280,08
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Jean Xavier Boucherle (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 391 758,39
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Andreas Stockhaus (Mr.)
"FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO ""DOCE DE OCTUBRE"""
Spain
EU contribution
€ 201 062,39
Address
Avenida De Cordoba Planta 4A - Edi
28041 Madrid
Activity type
Other
Administrative Contact
Mar López Martín (Dr.)
INSTITUT PASTEUR

Participation ended

France
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 410 260,38
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stewart Deakin (Mr.)
VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
Czechia
EU contribution
€ 175 940,59
Address
Technicka 5
166 28 Praha
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Mittnerova (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
EU contribution
€ 208 887,79
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Van Der Zande (Ms.)
anterio consult & research GmbH
Germany
EU contribution
€ 178 032,79
Address
Augustaanlage 23
68165 Mannheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Schneider (Mr.)
DC4U
Netherlands
EU contribution
€ 177 625,80
Address
De Corridor 21E
3621 ZA Breukelen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Schoevers (Mr.)
UNIVERSITE JOSEPH FOURIER GRENOBLE 1
France
EU contribution
€ 33 000
Address
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leslie Hollett (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 213 280,08
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Janil Slaout (Mr.)