Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Project Information

NANOTHER

Grant agreement ID: 213631

Project closed

Start date 1 September 2008

End date 31 August 2012

Funded under

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Total cost € 11 556 307,55

EU contribution € 8 408 483,00

Coordinated by

FUNDACION GAIKER
Spain

Objective

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

Fields of science

• medical and health sciences › clinical medicine › oncology › breast cancer
• medical and health sciences › clinical medicine › oncology › colorectal cancer
• engineering and technology › nanotechnology › nano-materials
• medical and health sciences › basic medicine › toxicology

Keywords

• RNAi
• biodistribution
• cancer
• diagnosis
• efficiency
• hyperthermia
• nanoparticle
• therapy
• toxicology

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Topic(s)

• NMP-2007-4.0-4 - Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy (in coordination with topic HEALTH-2007-2.4.1-7 and HEALTH-2007-1.2-3 in Theme 1 "Health")

Call for proposal

FP7-NMP-2007-LARGE-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FUNDACION GAIKER

• EU contribution: € 1 187 724,90
• Address: PARQUE TECNOLOGICO DE VIZCAYA, EDIFICIO 202 ; 48170 Zamudio ; Spain
• Region: Noreste › País Vasco › Bizkaia
• Activity type: Research Organisations
• Administrative Contact: Oscar Salas (Mr.)
• Total cost: No data

Participants (18)

TEL AVIV UNIVERSITY

Israel

• EU contribution: € 810 170,25
• Address: RAMAT AVIV ; 69978 Tel Aviv
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Lea Pais (Ms.)
• Total cost: No data

PHARMA MAR SA

Spain

• EU contribution: € 332 380,50
• Address: AVDA DE LOS REYES 1 POLIGONO INDUSTRIAL LA MINA COLMENAR VIEJO ; 28770 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Elena Calleja (Ms.)
• Total cost: No data

FEYECON DEVELOPMENT & IMPLEMENTATION BV

Netherlands

• EU contribution: € 121 800,00
• Address: HOGEWEYSELAAN 221 ; 1382 JL Weesp
• Region: West-Nederland › Noord-Holland › Het Gooi en Vechtstreek
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Annet. Helena Butter-Duits (Ms.)
• Total cost: No data

CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI

Italy

• EU contribution: € 951 284,00
• Address: VIA GIUSTI 9 ; 50121 Firenze
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Research Organisations
• Administrative Contact: Daniele Consigli (Mr.)
• Total cost: No data

AHAVA DEAD SEA LABORATORIES LTD

Israel

• EU contribution: € 256 492,50
• Address: ARAVA STREET 1 ; 70150 Airport City
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ofer Achdut (Mr.)
• Total cost: No data

ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH

Spain

• EU contribution: € 347 662,50
• Address: PASEO MIKELETEGI PARQUE TECNOLOGICO DE MIRAMON 57 ; 20009 DONOSTIA / SAN SEBASTIAN
• Activity type: Research Organisations
• Administrative Contact: Grégory Maclair (Dr.)
• Total cost: No data

COLOROBBIA ITALIA SPA

Italy

• EU contribution: € 505 700,00
• Address: VIA PIETRAMARINA 53 ; 50059 SOVIGLIANA VINCI
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Laura Niccolai (Dr.)
• Total cost: No data

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

Spain

• EU contribution: € 288 315,00
• Address: PARQUE TECNOLOGICO EDIFICIO 801 A ; 48160 DERIO VIZCAYA
• Region: Noreste › País Vasco › Bizkaia
• Activity type: Research Organisations
• Administrative Contact: Alfonso Egaña (Mr.)
• Total cost: No data

DOMINION PHARMAKINE S.L.

Participation ended

Spain

• EU contribution: € 158 295,05
• Address: BIZKAIA TECHNOLOGY PARK Building 801A ; 48160 DERIO
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Naiara Telleria (Dr.)
• Total cost: No data

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

• EU contribution: € 405 051,00
• Address: Rue de la Loi 200 ; 1049 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Clemens Wittwehr (Mr.)
• Total cost: No data

HAMELN RDS AS

Slovakia

• EU contribution: € 275 734,43
• Address: HORNA 36 ; 900 01 MODRA
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Anna Kovácová (Ms.)
• Total cost: No data

INSTITUT POLYTECHNIQUE DE BORDEAUX

France

• EU contribution: € 952 208,72
• Address: AV DU DOCTEUR ALBERT SCHWEITZER 1 ; 33402 Talence
• Region: Nouvelle-Aquitaine › Aquitaine › Gironde
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sebastien Lecommandoux (Prof.)
• Total cost: No data

TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS

Greece

• EU contribution: € 342 840,00
• Address: AGIOU SPYRIDONOS 28 KAI MILOU 1 ; 12210 AIGALEO
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ifigenia Anastasakou (Ms.)
• Total cost: No data

UNIVERSITE VICTOR SEGALEN BORDEAUX II

France

• EU contribution: € 326 016,00
• Address: RUE LEO SAIGNAT 146 ; 33076 BORDEAUX CEDEX
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jean-Michel Franconi (Prof.)
• Total cost: No data

NuovoProbe Ltd

United Kingdom

• EU contribution: € 278 692,00
• Address: Wigmore Street 128 ; W1U 3SA London
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Liz Spencer (Ms.)
• Total cost: No data

ARGUS CHEMICAL SRL

Italy

• EU contribution: € 120 848,15
• Address: VIA DEL MOLIN NUOVO 10 ; 59024 59024
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Enrico Ammannati (Dr.)
• Total cost: No data

AYMING

France

• EU contribution: € 343 880,00
• Address: RUE CHAPTAL 114 ; 92300 Levallois-Perret
• Region: Ile-de-France › Ile-de-France › Hauts-de-Seine
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nicolas Marin (Mr.)
• Total cost: No data

ACONDICIONAMIENTO TARRASENSE ASSOCIACION

Spain

• EU contribution: € 403 388,00
• Address: CARRER DE LA INNOVACIO 2 ; 08225 Terrassa
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Ciro Avolio (Mr.)
• Total cost: No data