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Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Objective

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/basic medicine/toxicology
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

FP7-NMP-2007-LARGE-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FUNDACION GAIKER
Address
Parque Tecnologico De Vizcaya, Edificio 202
48170 Zamudio
Spain
Activity type
Research Organisations
EU contribution
€ 1 187 724,90
Administrative Contact
Oscar Salas (Mr.)

Participants (18)

TEL AVIV UNIVERSITY
Israel
EU contribution
€ 810 170,25
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
PHARMAMAR, S.A.
Spain
EU contribution
€ 332 380,50
Address
Avda. De Los Reyes , Poligono Industrial La Mina 1
28770 Colmenar Viejo (Madrid)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elena Calleja (Ms.)
FEYECON DEVELOPMENT & IMPLEMENTATION BV
Netherlands
EU contribution
€ 121 800
Address
Rijnkade 17 A
1382 GS Weesp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annet. Helena Butter-Duits (Ms.)
CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI
Italy
EU contribution
€ 951 284
Address
Via Giusti 9
50121 Firenze
Activity type
Research Organisations
Administrative Contact
Daniele Consigli (Mr.)
AHAVA DEAD SEA LABORATORIES LTD
Israel
EU contribution
€ 256 492,50
Address
Arava Street 1
70150 Airport City
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ofer Achdut (Mr.)
ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH
Spain
EU contribution
€ 347 662,50
Address
Paseo Mikeletegi Parque Tecnologico De Miramon 57
20009 Donostia / San Sebastian
Activity type
Research Organisations
Administrative Contact
Grégory Maclair (Dr.)
COLOROBBIA ITALIA SPA
Italy
EU contribution
€ 505 700
Address
Via Pietramarina 53
50059 Sovigliana Vinci
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laura Niccolai (Dr.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
EU contribution
€ 288 315
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Activity type
Research Organisations
Administrative Contact
Alfonso Egaña (Mr.)
DOMINION PHARMAKINE S.L.

Participation ended

Spain
EU contribution
€ 158 295,05
Address
Bizkaia Technology Park Building 801A
48160 Derio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Naiara Telleria (Dr.)
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 405 051
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
Administrative Contact
Clemens Wittwehr (Mr.)
HAMELN RDS AS
Slovakia
EU contribution
€ 275 734,43
Address
Horna 36
900 01 Modra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anna Kovácová (Ms.)
INSTITUT POLYTECHNIQUE DE BORDEAUX
France
EU contribution
€ 952 208,72
Address
Av Du Docteur Albert Schweitzer 1
33402 Talence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sebastien Lecommandoux (Prof.)
TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS
Greece
EU contribution
€ 342 840
Address
Agiou Spyridonos 28 Kai Milou 1
122 10 Aigaleo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ifigenia Anastasakou (Ms.)
UNIVERSITE VICTOR SEGALEN BORDEAUX II
France
EU contribution
€ 326 016
Address
Rue Leo Saignat 146
33076 Bordeaux Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Michel Franconi (Prof.)
NuovoProbe Ltd
United Kingdom
EU contribution
€ 278 692
Address
Wigmore Street 128
W1U 3SA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Liz Spencer (Ms.)
ARGUS CHEMICAL SRL
Italy
EU contribution
€ 120 848,15
Address
Via Del Molin Nuovo 10
59024 59024
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Enrico Ammannati (Dr.)
AYMING
France
EU contribution
€ 343 880
Address
185 Avenue Des Gresillons
92622 Gennevilliers Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Marin (Mr.)
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
EU contribution
€ 403 388
Address
Carrer De La Innovacio 2
08225 Terrassa
Activity type
Research Organisations
Administrative Contact
Ciro Avolio (Mr.)