Objective The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives. Fields of science medical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicineoncologycolorectal cancerengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicinetoxicology Keywords RNAi biodistribution cancer diagnosis efficiency hyperthermia nanoparticle therapy toxicology Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-4.0-4 - Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy (in coordination with topic HEALTH-2007-2.4.1-7 and HEALTH-2007-1.2-3 in Theme 1 "Health") Call for proposal FP7-NMP-2007-LARGE-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator FUNDACION GAIKER Address Parque tecnologico de vizcaya, edificio 202 48170 Zamudio Spain See on map Region Noreste País Vasco Bizkaia Activity type Research Organisations Administrative Contact Oscar Salas (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 187 724,90 Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all TEL AVIV UNIVERSITY Israel EU contribution € 810 170,25 Address Ramat aviv 69978 Tel aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PHARMA MAR SA Spain EU contribution € 332 380,50 Address Avda de los reyes 1 poligono industrial la mina colmenar viejo 28770 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Administrative Contact Elena Calleja (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FEYECON DEVELOPMENT & IMPLEMENTATION BV Netherlands EU contribution € 121 800,00 Address Rijnkade 17 a 1382 GS Weesp See on map Region West-Nederland Noord-Holland Het Gooi en Vechtstreek Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Annet. Helena Butter-Duits (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI Italy EU contribution € 951 284,00 Address Via giusti 9 50121 Firenze See on map Region Centro (IT) Toscana Firenze Administrative Contact Daniele Consigli (Mr.) Links Contact the organisation Opens in new window Website Opens in new window AHAVA DEAD SEA LABORATORIES LTD Israel EU contribution € 256 492,50 Address Arava street 1 70150 Airport city See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ofer Achdut (Mr.) Links Contact the organisation Opens in new window ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH Spain EU contribution € 347 662,50 Address Paseo mikeletegi parque tecnologico de miramon 57 20009 Donostia / san sebastian See on map Activity type Research Organisations Administrative Contact Grégory Maclair (Dr.) Links Contact the organisation Opens in new window COLOROBBIA ITALIA SPA Italy EU contribution € 505 700,00 Address Via pietramarina 53 50059 Sovigliana vinci See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laura Niccolai (Dr.) Links Contact the organisation Opens in new window ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Spain EU contribution € 288 315,00 Address Parque tecnologico edificio 801 a 48160 Derio vizcaya See on map Region Noreste País Vasco Bizkaia Activity type Research Organisations Administrative Contact Alfonso Egaña (Mr.) Links Contact the organisation Opens in new window Website Opens in new window DOMINION PHARMAKINE S.L. Participation ended Spain EU contribution € 158 295,05 Address Bizkaia technology park building 801a 48160 Derio See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Naiara Telleria (Dr.) Links Contact the organisation Opens in new window Website Opens in new window JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 405 051,00 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Administrative Contact Clemens Wittwehr (Mr.) Links Contact the organisation Opens in new window Website Opens in new window HAMELN RDS AS Slovakia EU contribution € 275 734,43 Address Horna 36 900 01 Modra See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anna Kovácová (Ms.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT POLYTECHNIQUE DE BORDEAUX France EU contribution € 952 208,72 Address Av du docteur albert schweitzer 1 33402 Talence See on map Region Nouvelle-Aquitaine Aquitaine Gironde Activity type Higher or Secondary Education Establishments Administrative Contact Sebastien Lecommandoux (Prof.) Links Contact the organisation Opens in new window TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS Greece EU contribution € 342 840,00 Address Agiou spyridonos 28 kai milou 1 12210 Aigaleo See on map Activity type Higher or Secondary Education Establishments Administrative Contact Ifigenia Anastasakou (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE VICTOR SEGALEN BORDEAUX II France EU contribution € 326 016,00 Address Rue leo saignat 146 33076 Bordeaux cedex See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Michel Franconi (Prof.) Links Contact the organisation Opens in new window NuovoProbe Ltd United Kingdom EU contribution € 278 692,00 Address Wigmore street 128 W1U 3SA London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Liz Spencer (Ms.) Links Contact the organisation Opens in new window ARGUS CHEMICAL SRL Italy EU contribution € 120 848,15 Address Via del molin nuovo 10 59024 59024 See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Enrico Ammannati (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AYMING France EU contribution € 343 880,00 Address Rue chaptal 114 92300 Levallois-perret See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Administrative Contact Nicolas Marin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ACONDICIONAMIENTO TARRASENSE ASSOCIACION Spain EU contribution € 403 388,00 Address Carrer de la innovacio 2 08225 Terrassa See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Ciro Avolio (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
