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Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc

Objective

30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell-loaded bioactive polymer-based scaffolds will be developed. These will be designed to be implanted into the patient by minimally invasive surgery. A biomimetic approach will confer the appropriate mechanical and biological properties and enable the inclusion of the requisite cell signalling factors to produce a bio-hybrid structure which closely resembles the human tissue in all its essential attributes. Particular attention will be paid to angiogenesis. In IVD tissue, vascularization must be carefully controlled, due to the unique anatomy and physiology of the intervertebral disc. There must be negligible vascularization in the annulus and nucleus regions and moderate vascularization at the vertebral body level. Work will therefore be performed on materials functionalization, and on growth factor incorporation and delivery, to enable this region-specific control of vascularization at different levels. Natural IVD tissue contains a relatively low number of cells, which are chondrocyte-like in character. Consequently, it will be necessary to devote some research to identifying and evaluating suitable and more readily available alternative cells for incorporation in the bio-hybrid substitutes produced . Modelling studies will identify the physical and mechanical properties of the natural IVD and the substitute materials, and provide an understanding of the physical aspects of the regeneration process. In vivo study on animal model will be performed the bio-fuctionality of both sustitutes. Surgical methodology and protocol will be developed.

Call for proposal

FP7-NMP-2007-LARGE-1
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 977 431
Administrative Contact
Luigi Ambrosio (Prof.)

Participants (16)

ANIKA THERAPEUTICS SRL
Italy
EU contribution
€ 527 501
Address
Via Ponte Della Fabbrica 3B
35031 Abano Terme
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elisabetta Paolini (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 427 080
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Andrea Banfi (Dr.)
UNIVERSITY OF BRIGHTON
United Kingdom
EU contribution
€ 342 094
Address
Lewes Road Mithras House
BN2 4AT Brighton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Matteo Santin (Dr.)
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
EU contribution
€ 434 500
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
Administrative Contact
Virginia Fonseca (Dr.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain
EU contribution
€ 269 500
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Josep A. Planell (Prof.)
RISE IVF AB
Sweden
EU contribution
€ 311 256
Address
Argongatan 30
431 53 Molndal
Activity type
Other
Administrative Contact
Pernilla Walkenström (Dr.)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 318 250
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacinta Thornton (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 522 000
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Dr.)
UNIVERSIDAD DE ALICANTE
Spain
EU contribution
€ 318 058
Address
Campus De San Vicente Raspeig
03690 Alicante
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Josè Miguel Martin Martinez (Prof.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 295 742
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Abatangelo (Prof.)
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Romania
EU contribution
€ 310 750
Address
Splaiul Independentei 313 Sect 6
060042 Bucharest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Iulian Antoniac (Prof.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 438 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 422 000
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rui L. Reis (Prof.)
SOCIETA AZIONARIA MATERIALE OSPEDALIERO SAMO SPA
Italy
EU contribution
€ 327 440
Address
Via Matteotti 37
40057 Granarolo Dell Emilia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Enrico Sandrini (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 263 500
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 472 048
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
C. James Kirkpatrick (Prof.)