Project description Advanced ICT for Risk Assessment and Patient Safety Show the project objective Hide the project objective Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have already been exposed.In this project, an alternative approach for the detection of ADR signals will be developed. Rather than relying on the physician's capability and willingness to recognize and report suspected ADRs, the system will systematically calculate the occurrence of disease (potentially ADRs) during specific drug use based on data available in electronic patient records. In this project, electronic health records (EHRs) of over 30 million patients from several European countries will be available. In an environment where rapid signal detection is feasible, rapid signal assessment is equally important. To rapidly assess signals, a number of resources will be used to substantiate the signals: causal reasoning based on information in the EHRs, semantic mining of the biomedical literature, and computational analysis of biological and chemical information (drugs, targets, anti-targets, SNPs, pathways, etc.).The overall objective of this project is the design, development and validation of a computerized system that exploits data from electronic healthcare records and biomedical databases for the early detection of adverse drug reactions. The EU-ADR system will generate signals using data and text mining, epidemiological and other computational techniques, and subsequently substantiate these signals in the light of current knowledge of biological mechanisms and in silico prediction capabilities. The system should be able to detect signals better and faster than spontaneous reporting systems and should allow for identification of subpopulations at higher risk for ADRs. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacyadverse drug reactions Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2007.5.2 - Advanced ICT for risk assessment and patient safety Call for proposal FP7-ICT-2007-1 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Address Dr molewaterplein 40 3015 GD Rotterdam Netherlands See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Pieter Van Haren (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 216 639,00 Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all AARHUS UNIVERSITETSHOSPITAL Denmark EU contribution € 176 834,00 Address Palle juul-jensens boulevard 99 8200 Aarhus See on map Region Danmark Midtjylland Østjylland Activity type Research Organisations Administrative Contact John Westensee (Mr) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Spain EU contribution € 121 216,00 Address Colexio de san xerome praza do obradoiro s/n 15782 Santiago de compostela See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Administrative Contact María Isabel Loza (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES Spain EU contribution € 396 859,00 Address Doctor aiguader 88 08003 Barcelona See on map Region Este Cataluña Barcelona Administrative Contact Carlos Díaz Acedo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD POMPEU FABRA Spain EU contribution € 425 551,00 Address Placa de la merce, 10-12 08002 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Eva Martin (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE VICTOR SEGALEN BORDEAUX II France EU contribution € 289 800,00 Address Rue leo saignat 146 33076 Bordeaux cedex See on map Activity type Higher or Secondary Education Establishments Administrative Contact Nicholas Moore (Prof.) Links Contact the organisation Opens in new window SOCIETA SERVIZI TELEMATICI SRL Italy EU contribution € 179 825,00 Address Via medici giacomo 9/a 35138 Padova See on map Region Nord-Est Veneto Padova Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Silvia Faggion (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AGENZIA REGIONALE DI SANITA Italy EU contribution € 181 895,00 Address Via pietro dazzi 1 50141 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Administrative Contact Marco Menchini (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IRCCS CENTRO NEUROLESI BONINO PULEJO Participation ended Italy EU contribution € 137 150,00 Address Ctr casazza via palermo ss 113 98124 Messina See on map Region Isole Sicilia Messina Activity type Research Organisations Administrative Contact Giuseppe Galletta (Dr) Links Contact the organisation Opens in new window UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Italy EU contribution € 181 895,00 Address Piazza dell'ateneo nuovo 1 20126 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Giovanni Corrao (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Stichting Informatievoorziening voor Zorg en Onderzoek Netherlands EU contribution € 179 825,00 Address Van deventerlaan 3528AE Utrecht See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peggy Melinda Flenter (-) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDADE DE AVEIRO Portugal EU contribution € 286 650,00 Address Campus universitário de santiago 3810-193 Aveiro See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Administrative Contact José Fernando Ferreira Mendes (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ASTRAZENECA AB Sweden EU contribution € 220 116,00 Address Vastra maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Administrative Contact Scott Boyer (Dr) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 308 647,00 Address University park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Administrative Contact martin Wynne-Jones (Mr) Links Contact the organisation Opens in new window Website Opens in new window LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER United Kingdom EU contribution € 197 098,00 Address Keppel street WC1E 7HT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Penny Ireland (Ms) Links Contact the organisation Opens in new window Website Opens in new window
