Objective This Industry-Academia Partnership and Pathways (IAPP) joins three groups which have hitherto focused on different aspects of cancer genetics. deCODE genetics (deCODE) has recently identified several genetic risk variants that are associated with increased risk of cancer, including two distinct genetic prostate cancer risk variants on chromosome 8q24. The University of Torino (UNITO) group has identified a number of germline SNPs in signal transduction genes that are frequently mutated in tumors and the group has developed an innovative technology for knock-in of genetic variants in order to reconstruct genetic events in tumor progression. The Karolinska Institute (OP-KI) group has developed sophisticated tools for cytogenetic studies on tumors. The major objective of this proposal is to perform functional and cytogenetic analysis on several of the cancer risk variants identified by deCODE and UNITO. The major objectives of this proposal are 1) to discover and validate low-medium frequency polymorphisms that predispose to cancer, 2) to functionally validate the newly identified variants in human cells, 3) to identify biological properties associated with the prostate cancer risk alleles located at 8q24. Collaboration between deCODE, UNITO and OP-KI benefits all three partners since the capacities and technical skills are largely complementary. The collaboration is foreseen as an ongoing partnership aimed at elucidating the biological properties of genetic variants conferring risk of cancer. Fields of science medical and health sciencesclinical medicineoncologyprostate cancernatural sciencesbiological sciencesgeneticschromosomes Keywords Cancer genetic predisposition genetics population genomics tumor biology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-3-1-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2007-3-1-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator ISLENSK ERFDAGREINING EHF Address Sturlugotu 8 101 Reykjavik Iceland See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bjorgvin Richardsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 321 032,00 Address Via giuseppe verdi 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Maria Flavia Di Renzo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KAROLINSKA INSTITUTET Sweden EU contribution € 394 301,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Riitta Perttunen-Elo (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
