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Correlating protection against malaria with serum profiles against Plasmodium falciparum antigen repertoires

Objective

People living in malaria endemic areas develop, with time, a form of immunity to infection and clinical disease mediated by antibodies directed against P. falciparum antigens. Currently there are no assays or clinical parameters that predict whether an exposed person is protected against malaria. This represents a major obstacle for vaccine development. Here research institutions and industrial partners, combining cutting edge expertise in protein microarrays, immunoassay development, immunology, protein expression and epidemiology join their efforts with the objective of translating the genome sequence information of Plasmodium falciparum into a tool to unravel correlates of protection against human malaria. Recombinant P. falciparum proteins, encompassing the repertoire of secreted and surface antigens, will be printed onto microarrays to develop an immunoassay capable of unraveling antibodies directed against a vast number of parasite molecules. This assay will be utilized to compare the antigen-antibody recognition profiles of protected and non-protected persons in malaria-exposed communities, thus facilitating the identification of the antigens that either alone or in combination function as targets of protective immunity. The underlying project structure in terms of research activities, task distribution and management has been planned with the priority of facilitating the interactions of human resources, between academic institutions and industry. Exchange of staff and networking activities will bridge the scientific and cultural differences existing between the academic and industrial partners. Exchange of scientific knowledge and technical skill will unleash the full potential of the collective expertise of the participating laboratories towards the objectives of the proposal and will be instrumental in building collaborative links that will extend beyond the duration of the project.

Field of science

  • /medical and health sciences/health sciences/infectious disease/malaria

Call for proposal

FP7-PEOPLE-2007-3-1-IAPP
See other projects for this call

Funding Scheme

MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)

Coordinator

UNIVERSITA DEGLI STUDI DI PERUGIA
Address
Piazza Dell Universita 1
06123 Perugia
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 393 911
Administrative Contact
Vincenzo Nicola Talesa (Prof.)

Participants (5)

MICROTEST MATRICES LTD
United Kingdom
EU contribution
€ 462 558
Address
Exhibition Road, Bessemer Building
SW7 2AZ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Clelia Supparo (Ms.)
PX'Therapeutics
France
EU contribution
€ 376 005
Address
15, Rue Des Martyrs
38027 Grenoble
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tristan Rousselle (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 374 322
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eleanor Riley (Prof.)
MED BIOTECH LABORATORIES

Participation ended

Uganda
EU contribution
€ 144 754
Address
Lugwana Close, Myenga Tank Hill By-pass
0256 Kampala
Activity type
Research Organisations
Administrative Contact
Thomas Egwang (Dr.)
INFECTIOUS DISEASES RESEARCH COLLABORATION LIMITED
Uganda
EU contribution
€ 119 218
Address
New Mulago Hill Road
256 Kampala
Activity type
Research Organisations
Administrative Contact
Catherine Tugaineyo (Ms.)