Objective
Tumor necrosis factor alfa (TNF alfa) is a key pro-inflammatory cytokine that is produced and released mainly by monocytes and macrophages in response to an infectious organism. Unregulated release of TNF alfa may lead to chronic inflammation in the form o f an auto-immune disease, such as rheumatoid arthritis and Crohn's disease. TNF alfa was also shown to be involved in the development of several other disease states such as sepsis, multiple sclerosis, atherosclerosis, ischemic stroke, inflammation-linked cancer, and diabetes. Several inflammatory diseases are successfully treated by TNF alfa blockers, which are protein drugs and thus suffer from several major disadvantages. Attention in inflammation research has therefore focused on the development of smal l molecular weight inhibitors of TNF alfa production. A phospholipid-like synthetic molecule, ONO 2, was recently found to suppress lipopolysaccharide (LPS)-induced TNF alfa blood level. The mechanism of its activity is currently unknown. Since no endogeno us phospholipids are yet known to inhibit TNF alfa? production, we hypothesize that ONO 2 suppresses TNF alfa? via a novel pathway. The objective of the proposed research is to elucidate that TNF alfa modulating pathway. Specific aims are identification of the signaling components involved in ONO 2-mediated TNF alfa suppression, including: 1) A putative phospholipid-binding receptor and its endogenous ligand.2) Second messengers and early signaling events at the cell membrane. 3) Intracellular ONO 2-regulat ed signaling proteins.We expect that the information obtained by the proposed study will deepen our understanding of the molecular mechanisms which regulate TNF alfa production and will provide us with insights into how to interfere with this process, in order to treat inflammatory auto-immune diseases as well as other inflammation-linked diseases, in a novel therapeutic approach.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology autoimmune diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
TEL AVIV
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.