Objective
The objective of this proposal is to combine different computational methods to study the physics of specific cellular components and processes which involve biological macromolecules. We will especially concentrate on the study of polyelectrolye DNA chains and analogous biopolymers and will investigate on their interaction with cellular structures and on the mechanisms of modifications of their physical properties. The understanding gained will allow us to explore different cellular processes related to gene delivery such as self-assembly of cationic lipid-DNA complexes and membrane fusion, relevant because of their fundamental properties as well as their applications in the biomedical sector. To achieve this goal, it is necessary to reach time and length scales in which macromolecules evolve, a regime that is out of reach of standard modelling approaches. To this end, we intend to adopt and refine a new chemically-aware coarse grained scheme and use complementary state of the art modelling techniques such as atomistic molecular dynamics and unspecific coarse graining. In addition, supercomputing techniques and resources will be exploited to provide unique scientific insights. The proposal will benefit from the expertise in biomolecular studies of scientists at the Barcelona Biomedical Park (PRBB), which will guarantee feedback and a cross-field perspective to the management of the project and to the production and interpretation of scientific results. This project is very relevant to the goals of the IEF activity of the people work programme because of its ingrained multidisciplinary character and because it directly targets key research areas indicated by the EU such as biotechnology and nanotechnology. The different training and research activities planned would increase and diversify the scientific competences of the fellow, leading him to a more independent and mature professional status on which to build his future career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- engineering and technology nanotechnology
- natural sciences computer and information sciences computational science
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.