Final Report Summary - PTPS (Spatio-temporal regulation of growth factor signaling by PTPs in living cells)
Currently we are using CA-FLIM to systematically screen the PTP-ome for components of the signalling networks that act downstream EGFR activation. Finally, the molecular interactions and dynamic properties of protein tyrosine phosphatases are being studied by micro-spectroscopy techniques. This will provide relevant information about the subcellular partitioning of PTP activities inside the cell.
The following points are treated:
- Structure and dynamics of phospho-tyrosine signalling networks
- Regulation of EGFR phosphorylation by protein tyrosine phosphatises.