Objective
Neural stem cells provide throughout life a source of neuronal and glial progenitors in the central nervous system of mammals. In the adult brain, stem cells reside in specialized ‘niches’ which contain molecular and cellular signals capable of regulating their symmetric/asymmetric division, as well as specification and fate of their progeny. In the major neurogenic site, the forebrain subventricular zone (SVZ), the neural stem cells have been identified as a subpopulation of astrocytes originating from the embryonic radial glia. Occasionally, some of these astrocytes divide to give rise to transit amplifying cells that actively proliferate thus generating a neuronal, and to a lesser extent glial, progeny. Yet, the very mode, time, and pattern of cell division, as well as the mechanisms involved in its regulation within the stem cell niche are poorly understood. In this project, several techniques of living cell imaging and tracing, cell proliferation detection, and light, confocal, electron microscopic morphological analyses will be combined with the aim of visualizing and studying in vivo the process of neural stem cell division. Since brain neurogenic niches remarkably change postnatally, neural stem cell division will be analysed at different postnatal stages, through the transformation from radial glia to neurogenic astrocytes. These objectives, other than representing a crucial step in further understanding the neural stem cell biology within their niches, could be of importance in allowing new strategies aimed at modulating in situ the behaviour of mammalian neural stem cells as an innovative approach to brain repair.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences zoology mammalogy
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
10124 TORINO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.