Objective
The primary objective of this proposal is to physically eliminate malignant T and B cells that express Interleukin-2 receptor (IL2R) for treatment of certain leukemia/lymphomas and allogeneic organ transplant rejections. In recent years, therapeutic approa ches for hematological malignancies and allogeneic organ transplant rejections are moving away from non-specific cytotoxic to cell-specific treatment alternatives. The high-affinity IL-2R is primarily expressed in newly activated lymphocytes, including aut oimmune cells, abnormal T cells of patients with leukemia/lymphoma, and T cells of individuals rejecting allografts, but not in resting or memory lymphocytes. This aspect of IL-2R expression can be exploited to deliver proteins of interest, linked to IL-2, specifically into the cells. In this project, we propose to generate recombinant chimeric proteins consisting of IL-2 and cell death inducing proteins of human origin that will have the potential to treat these malignancies. These proteins will specifical ly induce cells’ own physiologic suicide mechanism by targeting the activation of the final executioner enzyme, caspase-3, of the system. The choice of biologics (chimeric proteins), the specificity, and the selected target of these biologics, ( activation of endogenous suicide mechanisms) to achieve cell death in IL-2R expressing cells make this proposal novel and significant. Therapeutic approaches using biologics, particularly of human origin, are conceivably much safer and effective than treat ments with nonbiological agents. If proved successful in vitro and in vivo in mice models of leukemia and/or transplantation, these novel regimens will have the potential to be applied to clinics in areas such as cancer, transplantation and autoimmunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine oncology leukemia
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
ANTALYA
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.