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Epigenetics and DNA repair. Is a chromatin remodeling process involved in the higher UV sensitivity of nucleotide excision repair defective cells?

Objective

The knowledge on regulatory roles of epigenetic mechanisms (heritable changes in the genome function without a change in the DNA sequence) has grown very fast during the last decade since they can be the target for treating several pathologies related to cancer and neurodegeneration. In the base of these diseases have also been found deficiencies in DNA repair mechanisms. In this respect, two human syndromes (Xeroderma Pigmentosum and Cockayne’s Syndrome) affecting one of the major DNA repair systems in human cells called nucleotide excision repair, characterized by sensitivity to UV irradiation, become an interesting model to contribute to unravel the link between chromatin remodeling processes and DNA repair. Expected results on the possible influence of chromatin remodeling processes to the higher sensitivity to UV radiation of Cockayne’s Syndrome cells will lead to perform further investigations to understand how these mechanisms are involved in the development of cancer and/or neurodegeneration found in these patients. Since the proposed investigation require a multidisciplinary study (cytogenetics, molecular biology and immunocytochemestry), it will become of the utmost importance not only for the research activity planned to carry out at the Laboratory of Prof. Palitti, since this line of research fits very well with the purposes already established by the Network of Excellence (NoE – Epigenetic Network created by several laboratories from Europe) supported by the FP6 program from the European Community; but also for having the possibility to incorporate new methodologies and strategies to continue with the study of possible links between epigenetic and DNA repair in our laboratory in Uruguay with the aim to initiate studies on epigenetic therapy mainly applied to facilitate chemotherapy treatment of cancer diseases.

Field of science

  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/biological sciences/genetics and heredity/dna
  • /natural sciences/biological sciences/genetics and heredity/nucleotide
  • /natural sciences/biological sciences/genetics and heredity/epigenetics
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

FP7-PEOPLE-2007-4-2-IIF
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Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITA DEGLI STUDI DELLA TUSCIA
Address
Via S Maria In Gradi 4
01100 Viterbo
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 233 872,25
Administrative Contact
Daniela Cicalini (Dr.)