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Persisting Transgenesis

Objective

For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize on recent discoveries in gene expression control to develop radical solutions to the problem of precisely controlling the fate and expression of exogenous genetic information in gene therapy with applications in these and other deadly diseases. Our proposal combines 20 of Europe’s outstanding experts from 8 countries in the field of genetic engineering for persisting gene expression. Partners have pioneered the use of Zinc Finger Nucleases, engineered recombinases and transposases for gene targeting, synthetic promoters, epigenetic switches and micro-RNA for regulating gene expression, developed state-of-the-art gene delivery platforms based on lentiviral, AAV and gutless adenoviral vectors, conducted front-line clinical trials, and productively collaborated in previous FP projects. PERSIST includes 16 work packages of which 6 focus on vector innovations (part A: emerging technologies), 6 on applications & evaluation (part B), 1 on process development and the remaining 2 on training/dissemination and project management including IPR issues. Targeting deadly diseases, such as inherited immunodeficiencies, storage disorders and haemophilias, PERSIST is in line with the Strategic Research Agenda (SRA) of the Innovative Medicines Initiative (IMI) and will result in: faster discovery and development of better medicines; more attractive professional environment for scientists; better European expertise and know-how to attract biomedical R&D investment in Europe; and a stronger competitive advantage for SMEs, spin-offs and start-ups to enhance Europe’s economy.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/medical biotechnology/genetic engineering

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITA VITA-SALUTE SAN RAFFAELE
Address
Via Olgettina 58
20132 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 974 143,80
Administrative Contact
Raffaella Voltolini (Dr.)

Participants (28)

NOVAMEN SAS

Participation ended

France
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 577 960
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Hélène Brun (Ms.)
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL
Germany
EU contribution
€ 457 905
Address
Paul-ehrlich-strasse 51-59
63225 Langen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Stefanie Larisch (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 826 774,44
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tobias Quick (Mr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 358 950
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lena Farneman Andersson (Ms.)
University College London
United Kingdom
EU contribution
€ 683 600
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany
EU contribution
€ 20 498,16
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Frädorf (Mr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 412 440
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anja Ehrhardt (Dr.)
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)

Participation ended

Germany
EU contribution
€ 244 503
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Research Organisations
Administrative Contact
Wolfgang Kuehlewind (Mr.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 411 400
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fabio Prati (Prof.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 411 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erika Eikens-Bedijn (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 935 150,01
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Henk Isselman (Mr.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 352 551
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Forsberg (Dr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 627 468
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
VIB VZW

Participation ended

Belgium
EU contribution
€ 284 403,60
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 350 151
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Fussenegger (Prof.)
ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
United Kingdom
EU contribution
€ 173 334
Address
Egham Hill University Of London
TW20 0EX Egham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jenny Febry (Ms.)
BIONTECH INNOVATIVE MANUFACTURING SERVICES GMBH
Germany
EU contribution
€ 328 596
Address
Vollmersbachstrasse 66
55743 Idar Oberstein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrea Schilz (Dr.)
ASSOCIATION GENETHON
France
EU contribution
€ 497 200
Address
Rue De L Internationale 1 Bis
91002 Evry
Activity type
Research Organisations
Administrative Contact
Jean-Philippe Marin (Mr.)
Eurofins Genomics Europe Sequencing GmbH
Germany
EU contribution
€ 497 550
Address
Jakob Stadler Platz 7
78467 Konstanz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Pohl (Mr.)
MOLECULAR MEDICINE SPA
Italy
EU contribution
€ 311 850
Address
Via Olgettina 58
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Enrico Cappelli (Dr.)
ACIES SAS

Participation ended

France
EU contribution
€ 19 529,19
Address
69 Rue De La République
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Duvarry (Mr.)
ACIES Consulting Group SAS
France
EU contribution
€ 260 470,81
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT
Spain
EU contribution
€ 66 276
Address
Avenida Complutense 40
28040 Madrid
Activity type
Research Organisations
Administrative Contact
Ana Collados Martin Posadillos (Ms.)
CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG
Germany
EU contribution
€ 60 000
Address
Paul Ehrlich Strasse 42-44
60596 Frankfurt
Activity type
Research Organisations
Administrative Contact
Robert Dornberger (Mr.)
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 564 635,40
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 207 212,59
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Juergen Dreyer (Mr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 265 859
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)