Objective For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize on recent discoveries in gene expression control to develop radical solutions to the problem of precisely controlling the fate and expression of exogenous genetic information in gene therapy with applications in these and other deadly diseases. Our proposal combines 20 of Europe’s outstanding experts from 8 countries in the field of genetic engineering for persisting gene expression. Partners have pioneered the use of Zinc Finger Nucleases, engineered recombinases and transposases for gene targeting, synthetic promoters, epigenetic switches and micro-RNA for regulating gene expression, developed state-of-the-art gene delivery platforms based on lentiviral, AAV and gutless adenoviral vectors, conducted front-line clinical trials, and productively collaborated in previous FP projects. PERSIST includes 16 work packages of which 6 focus on vector innovations (part A: emerging technologies), 6 on applications & evaluation (part B), 1 on process development and the remaining 2 on training/dissemination and project management including IPR issues. Targeting deadly diseases, such as inherited immunodeficiencies, storage disorders and haemophilias, PERSIST is in line with the Strategic Research Agenda (SRA) of the Innovative Medicines Initiative (IMI) and will result in: faster discovery and development of better medicines; more attractive professional environment for scientists; better European expertise and know-how to attract biomedical R&D investment in Europe; and a stronger competitive advantage for SMEs, spin-offs and start-ups to enhance Europe’s economy. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural scienceschemical sciencesinorganic chemistrytransition metals Keywords Clinical applications Gene targeting Gene therapy Gutless adenoviral vector Hemophilias Immunodeficiencies Inherited diseases Lentiviral vectors Site-specific gene editing Storage disorders Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.4-4 - Development of emerging gene therapy tools and technologies for clinical application Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITA VITA-SALUTE SAN RAFFAELE EU contribution € 974 143,80 Address VIA OLGETTINA 58 20132 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Raffaella Voltolini (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (28) Sort alphabetically Sort by EU Contribution Expand all Collapse all NOVAMEN SAS Participation ended France EU contribution No data Address Rue de la République 69 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vincent Grosbois (Mr.) Links Contact the organisation Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 577 960,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Hélène Brun (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL Germany EU contribution € 457 905,00 Address PAUL-EHRLICH-STRASSE 51-59 63225 Langen See on map Region Hessen Darmstadt Offenbach, Landkreis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Stefanie Larisch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution € 826 774,44 Address Carl-Neuberg-Strasse 1 30625 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Tobias Quick (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 358 950,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Lena Farneman Andersson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 683 600,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Participation ended Germany EU contribution € 20 498,16 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Frädorf (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 412 440,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Anja Ehrhardt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Participation ended Germany EU contribution € 244 503,00 Address ROBERT ROSSLE STRASSE 10 13125 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Wolfgang Kuehlewind (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA Italy EU contribution € 411 400,00 Address VIA UNIVERSITA 4 41121 Modena See on map Region Nord-Est Emilia-Romagna Modena Activity type Higher or Secondary Education Establishments Administrative Contact Fabio Prati (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 411 000,00 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Erika Eikens-Bedijn (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 935 150,01 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Henk Isselman (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX IV Laboratory, Lund University Sweden EU contribution € 352 551,00 Address Paradisgatan 5c 22100 LUND See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Jens Forsberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 627 468,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Bettina Crispin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIB VZW Participation ended Belgium EU contribution € 284 403,60 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 350 151,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Martin Fussenegger (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE United Kingdom EU contribution € 173 334,00 Address EGHAM HILL UNIVERSITY OF LONDON TW20 0EX Egham See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Higher or Secondary Education Establishments Administrative Contact Jenny Febry (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIONTECH INNOVATIVE MANUFACTURING SERVICES GMBH Germany EU contribution € 328 596,00 Address VOLLMERSBACHSTRASSE 66 55743 IDAR OBERSTEIN See on map Region Rheinland-Pfalz Koblenz Birkenfeld Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andrea Schilz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSOCIATION GENETHON France EU contribution € 497 200,00 Address RUE DE L INTERNATIONALE 1 BIS 91002 Evry See on map Region Ile-de-France Ile-de-France Essonne Activity type Research Organisations Administrative Contact Jean-Philippe Marin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SANGER PCR GMBH Germany EU contribution € 497 550,00 Address JAKOB STADLER PLATZ 7 78467 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Pohl (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGC BIOLOGICS SPA Italy EU contribution € 311 850,00 Address VIA MEUCCI, 3 20091 BRESSO MI See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Enrico Cappelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACIES SAS Participation ended France EU contribution € 19 529,19 Address 69 Rue de la République 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Duvarry (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACIES Consulting Group SAS France EU contribution € 260 470,81 Address rue de la République 69 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vincent Grosbois (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRO DE INVESTIGACIONES ENERGETICAS MEDIOAMBIENTALES Y TECNOLOGICAS Spain EU contribution € 66 276,00 Address AVENIDA COMPLUTENSE 40 28040 MADRID See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Ana Collados Martin Posadillos (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG Germany EU contribution € 60 000,00 Address PAUL EHRLICH STRASSE 42-44 60596 Frankfurt See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Robert Dornberger (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VRIJE UNIVERSITEIT BRUSSEL Belgium EU contribution € 564 635,40 Address PLEINLAAN 2 1050 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Administrative Contact Maria Vereeken (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution € 207 212,59 Address HUGSTETTER STRASSE 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Juergen Dreyer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE Italy EU contribution € 265 859,00 Address VIA OLGETTINA 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maria Rosa Pedrazzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data