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Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

Objective

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.

Field of science

  • /natural sciences/physical sciences/acoustics/ultrasound
  • /medical and health sciences/clinical medicine/cardiology
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 632 071
Administrative Contact
Marco Borbotti (Mr.)

Participants (21)

TURUN YLIOPISTO
Finland
EU contribution
€ 450 023,09
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 92 706
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Philipp Kaufmann (Prof.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 199 115,02
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sietske Hoekstra-Byvank (Ms.)
TECHNISCHE UNIVERSITAET MUENCHEN

Participation ended

Germany
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inge Linder (Ms.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Spain
EU contribution
€ 12 883,59
Address
Calle Sant Antoni M Claret 167
08025 Barcelona
Activity type
Research Organisations
Administrative Contact
Hilda Herrero (Ms.)
INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO
Poland
EU contribution
€ 89 980,81
Address
Ul. Alpejska 42
04628 Warszawa
Activity type
Research Organisations
Administrative Contact
Liliana Chojnacka (Ms.)
ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 95 272,12
Address
Sydney Street
SW3 6NP London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
George Karagiannis (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 84 513,16
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 112 821,36
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Angela Ferrera (Ms.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 107 893,24
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
José Francisco Soto Bonel (Mr.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 45 032,36
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata D'amico (Ms.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 56 265,54
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Santiago Aguade (Dr.)
SOCIETE EUROPEENNE DE CARDIOLOGIE
France
EU contribution
€ 28 180
Address
Route Des Colles 2035
06903 Biot Sophia Antipolis
Activity type
Other
Administrative Contact
Francoise Heraud (Ms.)
INFORSENSE LIMITED

Participation ended

United Kingdom
EU contribution
€ 46 740,90
Address
Hammersmith Road Colet Court 100
W6 7JP London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Naughalty (Mr.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
EU contribution
€ 79 661,10
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Ms.)
FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA
Italy
EU contribution
€ 233 031,84
Address
Via Trieste 41
56126 Pisa
Activity type
Research Organisations
Administrative Contact
Luciano Ciucci (Dr.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 98 962,99
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein (Ms.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 120 247,88
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanya Szendeffy (Ms.)
AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
Italy
EU contribution
€ 40 000
Address
Via Delle Oblate 1
50139 Firenze
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mariagrazia Catania (Ms.)
Azienda U.S.L. N. 12 di Viareggio
Italy
EU contribution
€ 30 000
Address
Via Aurelia 335
55041 Lucca
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Claudio Rapalini (Dr.)
KLINIKEN DES LANDKREISES GOPPINGEN GGMBH
Germany
EU contribution
€ 40 000
Address
Eichertstrasse 3
73035 Goppingen
Activity type
Research Organisations
Administrative Contact
Jörg Martin (Prof.)