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European Network for Advanced Research on Olfaction for Malaria Transmitting Insect Control

Objective

The specificity of odor recognition by Anopheles gambiae odorant binding proteins (OBPs) and odorant receptors (ORs) will be investigated and correlated with quantifiable physiological and behavioral responses. For olfactory proteins involved in the detection of human hosts, OBP-OR pairs residing in common antennal olfactory sensilla and recognizing common host-related ligands will be identified using high-throughput screening assays employing purified recombinant OBPs, reconstituted insect cell-based OR expression platforms and libraries of synthetic and natural compounds. OBP crystal-based structure determination and modeling of ligand fitting into OBP and OR ligand-binding pockets will also be carried out in order to design ligand mimetics with improved binding and functional properties. The effectiveness of newly identified ligands will be established by in vivo electrophysiological and behavioral assays on female mosquitoes. Finally, lead compounds acting as disruptors of normal olfactory and host seeking mosquito behavior but lacking mammalian cell toxicity will be tested in model sites in Africa where A. gambiae (and malaria) is endemic to determine efficacy characteristics under conditions that simulate the sites of possible application of newly developed products. This approach to dissecting mosquito vector olfactory function should yield results that will enhance our understanding of the mechanisms that control odor recognition in mosquitoes. The identification of multiple disruptors of host seeking behavior of female mosquitoes will provide multiple new and effective tools to be employed in the effort to reduce the incidence of contact between the human host and the insect vector carrying the malaria parasite. Last but not least, the outcome of the proposed studies should serve as a paradigm for analogous efforts aimed at a reduction in disease transmission by other disease-carrying insect vectors.

Call for proposal

FP7-HEALTH-2007-B
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Coordinator

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Greece
Activity type
Research Organisations
EU contribution
€ 563 000
Administrative Contact
Papadopoulos Euripides (Mr.)

Participants (11)

NIGERIAN INSTITUTE OF MEDICAL RESEARCH
Nigeria
EU contribution
€ 69 000
Address
Edmond Crescent 6
101011 Lagos
Activity type
Research Organisations
Administrative Contact
T. Samson Awolola (Dr.)
Inscent, Inc.
United States
EU contribution
€ 216 000
Address
Sky Park Circle 17905 Suite P
92614 Irvine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Woods (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 246 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Beatrice Saint-Cricq (Ms.)
ROTHAMSTED RESEARCH LIMITED
United Kingdom
EU contribution
€ 261 000
Address
West Common
AL52JQ Harpenden
Activity type
Research Organisations
Administrative Contact
Stephen James (Mr.)
UNIVERSITE DE NEUCHATEL
Switzerland
EU contribution
€ 240 000
Address
Faubourg De L'hopital 41
2000 Neuchatel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Patrick Guerin (Dr.)
UNIVERSITAET HOHENHEIM
Germany
EU contribution
€ 210 000
Address
Schloss Hohenheim
70599 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans-Peter Liebig (Prof.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 210 000
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Dimitrios Kyriakidis (Prof.)
NEUROPROOF GMBH
Germany
EU contribution
€ 130 000
Address
Friedrich Barnewitz Str 4
18119 Rostock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olaf Schröder (Dr.)
UNIVERSITA DI PISA
Italy
EU contribution
€ 145 000
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leda Fenili (Dr.)
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
EU contribution
€ 120 000
Address
Temesvari Korut 62
6726 Szeged
Activity type
Research Organisations
Administrative Contact
János Báthori (Dr.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 90 000
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefano Turillazzi (Prof.)