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New Approaches to Target Tuberculosis

Objective

The increasing emergence of multidrug resistant strains and extensively drug resistant strains, the last one being virtually untreatable, urgently demand novel drugs for therapy of tuberculosis. This project has the aim of bringing together a number of research scientists with expertise in a broad range of disciplines, both from Europe and from India, covering the development field from chemistry to in vivo evaluation. The selected targets belong to either the group of targets from which some proof of concept already exist (mycolic acid synthesis and ATP synthase) either to the group of completely new targets that will be validated (thymidylate synthase, acyl-CoA carboxylase, DNA helicases). One alternative strategy to target the host cellular machinery to enhance bacterial killing is, likewise, included. The selected targets are covering fatty acid metabolism, nucleoside synthesis, energy generator, the survival of the microorganism in macrophages, the nucleic acids metabolism. The systems selected include those from which we expect to generate compounds active against replicating mycobacteria or to obtain compounds targeting latent infection. The application is divided in four scientific workpackages, including target validation, the interaction with the host cellular machinery, the design and synthesis of new inhibition and in vitro and in vivo screening of drug candidates and one management workpackage. A considerable part of the drug development and assessment against drug resistant Mycobacterium tuberculosis will be carried out by the Indian partners, one of which is an SME.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids
  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 608 000
Administrative Contact
Maria Vereeken (Ms.)

Participants (7)

Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 1 052 135
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Gieding (Ms.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 404 640
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jaana Evander (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 453 463
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Michele Marron (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 245 720
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY
India
EU contribution
€ 55 800
Address
Aruna Asaf Ali Marg
110067 New Delhi
Activity type
Research Organisations
Administrative Contact
P Dahra (Mr.)
National Institute of Pharmaceutical Education and Research
India
EU contribution
€ 86 400
Address
Sector-67 Phase-x
160 062 S. A. S. Nagar
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
P. Rama Rao (Prof.)
Institute of Molecular Medicine
India
EU contribution
€ 88 320
Address
Salt Lake Electronics Complex, Bengal Intelligent Park, Building B Block Ep & Gp
700091 Kolkata
Activity type
Research Organisations
Administrative Contact
Rakesh Pandya (Mr.)