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Molecular coding and subset specification of dopamine neurons generating the the meso-limbic and nigro-striatal system

Objective

This project aims to elucidate the molecular coding of meso-diencephalic dopaminergic (mdDA) neurons forming the complex meso-limbic and nigro-striatal dopaminergic system in the vertebrate central nervous system. Recent advances in molecular and developmental biology have shown that this system harbors u multitude of functional units that are defined by spatial and temporal cues and are represented by specific molecular codes. These codes are essential to understand specific mdDA neuronal pathology as Parkinson's diseases and schizophrenia. In this collaborative project we gather the expertise on early and late development, cross species molecular-coding conservation, migration and axonal pathfinding to capture the significance of the understanding of mdDA neuronal development to generate a real advance in clinical understanding and treatment of mdDA pathology.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/biological sciences/developmental biology
  • /medical and health sciences/clinical medicine/psychiatry/schizophrenia
  • /social sciences/sociology/social problems/migration
  • /medical and health sciences/basic medicine/neurology/parkinson

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 750 937
Administrative Contact
Marten P. Smidt (Prof.)

Participants (6)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 300 100
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riitta Ljungstrom (Ms.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 319 680
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Klaus Duformantel (Mr.)
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
EU contribution
€ 309 570
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rafael Gandía-Balaguer (Mr.)
CEINGE BIOTECNOLOGIE AVANZATE SCARL
Italy
EU contribution
€ 300 890
Address
Via Gaetano Salvatore 486
80145 Napoli
Activity type
Research Organisations
Administrative Contact
Saverio Petrocelli (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 299 972
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 301 600
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Franck Charron (Mr.)