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Exploiting Nanobodies in development of new diagnostic tools and treatment methods for Trypanosomiasis

Objective

African trypanosomiasis is in need of new diagnostic detection tools and new treatment methods. To date the widely used card agglutination test for trypanosomiasis is not very specific as the test is based on the screening for cross-reactive host antibodies. The availability of treatment for Trypanosmiasis on the other hand is limited due to the fact that only very few drugs are registered for use, and all can cause serious side effects in treated patients or animals. Hence, this project will focus on the development of new and innovative diagnosis and treatment tools, using the nanobody technology that has been developed by the coordinating partner of this network. Nanobodies are small single domain antibody fragments that have unique properties that include their capacity to recognize particular epitopes (not recognized by conventional antibodies) and their improved stability. In addition, they can be used as molecular target- or transport devices of other biological active components. As such they are excellent tools to support this project. Despite the fact that the coordinating laboratory has been a pioneer in differential molecular characterization of African trypanosomes and were involved in the initial release of diagnostic PCR methods that have now been adopted by many other research groups, this project will deliberately adopt a different approach. Indeed, in comparison to nanobody technology, PCR based diagnostics are much more costly and require an infrastructure that is hard to sustain over prolonged periods of time in African ‘field situations’. The simplicity of the nanobody technology on the other hand makes it an excellent topic for knowledge transfer. Despite it’s high-technology approach, the technique it will be relatively easy to be adopted by laboratories of participating African partner groups.

Field of science

  • /social sciences/social and economic geography/transport

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

VIB VZW
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium
Activity type
Research Organisations
EU contribution
€ 859 320

Participants (5)

ARTTIC IN BRUSSELS SPRL
Belgium
EU contribution
€ 205 200
Address
Rue De Livourne 7 Bte 4
1060 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NATIONAL MUSEUMS OF KENYA*INSTITUTE OF PRIMATE RESEARCH
Kenya
EU contribution
€ 405 424
Address
Pobox 24481
00502 Nairobi
Activity type
Research Organisations
UNIVERSIDADE EDUARDO MONDLANE
Mozambique
EU contribution
€ 374 424
Address
Reitoria Da Universidade, Praca 25 De Junho 257
00200 Maputo
Activity type
Higher or Secondary Education Establishments
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS
Switzerland
EU contribution
€ 283 296
Address
Campus Biotech, Chemin Des Mines 9
1202 Geneve
Activity type
Other
FUNDACION PARA LA INVESTIGACION BIOSANITARIA DE ANDALUCIA ORIENTAL-ALEJANDRO OTERO
Spain
EU contribution
€ 586 944
Address
Avd. Fuerzas Armadas 2
18014 Granada
Activity type
Research Organisations