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The appropriateness of prescribing antibiotics in primary health care in Europe with respect to antibiotic resistance

Objective

The APRES project aims at providing information and recommendations on the appropriateness of prescribing antibiotics in primary care. The appropriateness of prescribing antibiotics is the extent to which the pattern of prescribed antibiotics is congruent with the antibiotic resistance pattern of bacteria. More than 90% of antibiotics in Europe is prescribed to non-hospitalized patients, but existing information on the antibiotic resistance pattern is exclusively based on samples from hospitalized patients. Guidelines for prescribing antibiotics to outpatients cannot be based on empirical evidence about antibiotic resistance of bacteria circulating in the community because this evidence is lacking. The APRES project contains 4 work packages. WP1 includes a) a systematic review on the relationship between outpatient consumption of antibiotics and patterns of antibiotic resistance of pathogens circulating in the community; b) the establishment of a database of information sources and databases in nine European countries on outpatient consumption of antibiotics and antibiotic resistance patterns of pathogens circulating in the community. In WP2 the antibiotic resistance pattern of S. aureus and S. pneumoniae will be established in nine European countries, based on samples from healthy persons consulting in primary care practices participating in nationally representative networks. In WP3 we will establish the 5-year pattern of prescribed antibiotics the same practices and its variation between nine European countries. The data will be retrieved from electronic medical records in the same primary care practices. WP4 includes the integrative analyses by linking the antibiotic prescribing data with the antibiotic resistance patterns obtained in the same practices to establish the appropriateness of prescribing antibiotics. On the basis of these results, country specific guidelines will be formulated for appropriate prescribing of antibiotics.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING NEDERLANDS INSTITUUT VOOR ONDERZOEK VAN DE GEZONDHEIDSZORG
Address
Otterstraat 118-124
3500 BN Utrecht
Netherlands
Activity type
Research Organisations
EU contribution
€ 882 244,46
Administrative Contact
Robert Dessing (Mr.)

Participants (13)

THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 139 480,94
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 701 420
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erie Van Den Heuvel (Mr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 300 520
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
THE ROYAL COLLEGE OF GENERAL PRACTITIONERS
United Kingdom
EU contribution
€ 77 520
Address
Princes Gate - Hyde Park 14
SW7 1PU London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ruth Palmer (Ms.)
SOCIETE FRANCAISE DE MEDECINE GENERALE
France
EU contribution
€ 90 160
Address
Avenue De Verdun 141
92130 Issy Les Moulineaux
Activity type
Research Organisations
Administrative Contact
Gilles Hebrecht (Dr.)
SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET
Croatia
EU contribution
€ 94 960
Address
Salata 3
10 000 Zagreb
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Smiljka Vikić-Topić (Ms.)
ALLGEMEIN OFFENTLICHES KRANKENHAUS DER ELISABETHINEN
Austria
EU contribution
€ 35 736
Address
Fadingerstrasse 1
4010 Linz
Activity type
Research Organisations
Administrative Contact
Petra Apfalter (Dr.)
NORTH BRISTOL NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 34 560
Address
Southmead Hospital, Southmead Road, Westbury On Trym
BS10 5NB Bristol
Activity type
Research Organisations
Administrative Contact
Andrew Lovering (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 81 034
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manfred Maier (Prof.)
FUNDACIO INSTITUT UNIVERSITARI PERA LA RECERCA A L'ATENCIO PRIMARIA DE SALUT JORDI GOL I GURINA
Spain
EU contribution
€ 110 776
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Research Organisations
Administrative Contact
José Maria Gállego
DEBRECENI EGYETEM
Hungary
EU contribution
€ 87 400
Address
Egyetem Ter 1
4032 Debrecen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gábor Kecskés (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 79 384
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Ms.)
JONKOPINGS LAN
Sweden
EU contribution
€ 94 315,60
Address
Husargatan 4
S-55111 Jonkoping
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Boel Andersson-Gare (Prof.)