Objective A broad-range of candidate malaria vaccines derived from diverse novel technologies have resulted from the multiple approaches being taken by different groups in developing malaria vaccines. The majority of the candidates are recombinant proteins based on complex native antigens found on the surface of the parasite. Vaccine potential of these parasite surface antigens is often supported by epidemiological data, and by the ability to induce specific antibodies or potential protective responses in animals and later, in humans. Individual groups have developed assays within the context of the vaccine discovery efforts, with identification of measurable processes for parasite growth and virulence to test specific antigens. In-house assays are strain, stage and even process specific and the ability to compare results between different candidates is further limited by diverse methodologies and assay components such as parasites, cells and reagents. The absence of some level of harmonization of practices also makes interpreting the meaning and relevance of vaccine research outcomes complex. Lack of an enabling environment for comparability of research results generated in different labs could unfortunately lead to scepticism of the results that in turn generate uncertainty about the efficacy of the vaccines and rationale of the development pathway. To compare the relative merits of different candidate vaccines and approaches in a credible and informed manner, efforts must be made to create this enabling environment by supporting the development of a baseline level of standardization around key assays that can be utilized a) in the evaluation of malaria vaccines, and b) throughout the Development process. Consistent, reproducible and comparable intra- and inter-lab performance and increased accuracy and precision of assay data, will strengthen the quality of the data on vaccine performance and generate greater confidence in the vaccine potential of the candidate. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Keywords EMVI OPTIMALVAC WHO assays evaluation malaria vaccine Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.2-13 - Coordination of European research activities with global initiatives, including Public-Private Partnerships Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CSA-CA - Coordination (or networking) actions Coordinator EUROPEAN VACCINE INITIATIVE EWIV EU contribution € 294 512,11 Address VOSSSTRASSE 2 GEB 4040 69115 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Odile Leroy (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT PASTEUR France EU contribution € 100 000,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER Netherlands EU contribution € 55 224,00 Address LANGE KLEIWEG 161 2288 GJ Rijswijk Zh See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Research Organisations Administrative Contact Alan William Thomas (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STOCKHOLMS UNIVERSITET Participation ended Sweden EU contribution No data Address UNIVERSITETSVAGEN 10 10691 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Klavs Berzins (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 135 000,00 Address OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 40 794,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Gary Strickland (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 130 000,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Bruinenberg (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WORLD HEALTH ORGANIZATION Switzerland EU contribution € 180 000,00 Address Avenue Appia 20 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Research Organisations Administrative Contact Saladin Osmanov (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PATRICE MARTIN DUBOIS - IMMUNOVACC CONSULTING Belgium EU contribution No data Address RUE COLONEL CHALTIN 49 1180 BRUXELLES See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrice Dubois (Dr.) Links Contact the organisation Opens in new window Total cost No data PROGRAM FOR APPROPRIATE TECHNOLOGYIN HEALTH United States EU contribution No data Address Leary WAY NW 1455 98107-5136 Seattle Wa See on map Activity type Research Organisations Administrative Contact Christian Loucq (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Spain EU contribution € 50 000,00 Address C ROSSELLO 08036 Barcelona See on map Administrative Contact Pau Balcells (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HEALTH PROTECTION AGENCY HPA United Kingdom EU contribution No data Address BUCKINGHAM PALACE ROAD 151 SW1W 9SZ London See on map Activity type Research Organisations Administrative Contact Barry Walker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data United States Department of Health and Human Services United States EU contribution No data Address Independence Avenue S. W. 200 20201 Washington D.C. See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ya Ping Shi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STATENS SERUM INSTITUT Participation ended Denmark EU contribution € 14 469,89 Address ARTILLERIVEJ 5 2300 Kobenhavn S See on map Region Danmark Hovedstaden Byen København Activity type Research Organisations Administrative Contact Odile Leroy (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data