Objective The RETICIR project focuses on neuronal mechanisms of vision from photoreceptor level to visual cortex. Physiological knowledge of the visual system will be used to address pathophysiological neuronal mechanisms of diseases affecting vision. In the project we will identify molecular and cellular disease mechanism of retinitis pigmentosa and glaucoma, and will demonstrate restoration of vision in retinas with degenerated photoreceptors from single neuronal responses in the retina all the way to cortical visual evoked responses and behavioral assays.Blindness in man often results from dysfunction of the retina. For a number of retinal diseases, the retinal circuitry is a major part of the problem. Effective strategies for treatment of those diseases and for all attempts to restore vision, understanding of the retinal circuitries is essential. Our strategy is that understanding the structure and function of specific retinal circuits should be used to find therapies to retinal diseases, like for instance retinitis pigmentosa and glaucoma. Specific circuits can be only studied with cell type specific promoters and therefore the methodology that we will use is the combination of in vivo marked cell types with genetic interference with the function of these cells and state of the art physiological and behavioral approaches. Fields of science medical and health sciencesclinical medicineophthalmologyglaucoma Keywords Channelrhodopsin Glaucoma Neuroprotection Photoreceptor degeneration Restoration of Vision Retinal circuitry Retinitis pigmentosa Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases HEALTH-2007-2.2.1-9 - Neuronal mechanisms of vision and related diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Address Kloveniersburgwal 29 het trippenhuis 1011 JV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Administrative Contact Maarten Kamermans (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 481 900,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 228 900,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Enide Noupian (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CARL VON OSSIETZKY UNIVERSITAET OLDENBURG Germany EU contribution € 461 400,00 Address Ammerlaender heerstrasse 114-118 26129 Oldenburg See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Sabine Geruschke (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Novartis Forschungsstiftung Switzerland EU contribution € 461 400,00 Address Maulbeerstrasse 66 4058 Basel See on map Activity type Research Organisations Administrative Contact Botond Roska (Dr.) Links Contact the organisation Opens in new window Website Opens in new window University of Zurich Switzerland EU contribution € 461 400,00 Address Ramistrasse 71 8006 Zurich See on map Activity type Higher or Secondary Education Establishments Administrative Contact Stephan Neuhauss (Prof.) Links Contact the organisation Opens in new window Website Opens in new window INSERM TRANSFERT SA France EU contribution € 155 000,00 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
