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Circuit specific approaches to retinal diseases

Objective

The RETICIR project focuses on neuronal mechanisms of vision from photoreceptor level to visual cortex. Physiological knowledge of the visual system will be used to address pathophysiological neuronal mechanisms of diseases affecting vision. In the project we will identify molecular and cellular disease mechanism of retinitis pigmentosa and glaucoma, and will demonstrate restoration of vision in retinas with degenerated photoreceptors from single neuronal responses in the retina all the way to cortical visual evoked responses and behavioral assays.Blindness in man often results from dysfunction of the retina. For a number of retinal diseases, the retinal circuitry is a major part of the problem. Effective strategies for treatment of those diseases and for all attempts to restore vision, understanding of the retinal circuitries is essential. Our strategy is that understanding the structure and function of specific retinal circuits should be used to find therapies to retinal diseases, like for instance retinitis pigmentosa and glaucoma. Specific circuits can be only studied with cell type specific promoters and therefore the methodology that we will use is the combination of in vivo marked cell types with genetic interference with the function of these cells and state of the art physiological and behavioral approaches.

Field of science

  • /medical and health sciences/clinical medicine/ophthalmology/glaucoma
  • /medical and health sciences/clinical medicine/ophthalmology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands
Activity type
Other
EU contribution
€ 481 900
Administrative Contact
Maarten Kamermans (Prof.)

Participants (5)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 228 900
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Enide Noupian (Ms.)
CARL VON OSSIETZKY UNIVERSITAET OLDENBURG
Germany
EU contribution
€ 461 400
Address
Ammerlaender Heerstrasse 114-118
26129 Oldenburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sabine Geruschke (Mr.)
Novartis Forschungsstiftung
Switzerland
EU contribution
€ 461 400
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Botond Roska (Dr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 461 400
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Stephan Neuhauss (Prof.)
INSERM TRANSFERT SA
France
EU contribution
€ 155 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)