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Development of cardiomyocyte replacement strategy for the clinic

Objective

Heart failure as a result of myocardial infarction or ischemic heart disease is a major health problem in Europe. Currently the only long term solution is heart transplantation but one in three patients die while awaiting a match. Transplantation of an alternative cell source is extremely attractive but has so far met with very little success. Thus, skeletal muscle myoblasts led to recurrent arrhythmias with potential lethal effects, whereas the hopes for bone marrow transplantation have been largely dashed by the low efficiency and lack of evidence for trans-differentiation. In this project, we plan to mount a concerted and integrated effort to identify cells within the adult and developing heart with repair potential. We will characterise the cells to enhance their purification from, or stimulation within, foetal or adult tissue. In addition, we will determine how they are made during embryonic development to further improve the chances of manipulating their activity in vivo and also to increase the efficiency of their generation from embryonic stem cells. Cardiomyocytes generated in any of these ways will be genetically profiled and physiologically tested, both in vitro and after transplantation, to ensure their proper functional integration into the resident myocardium. In preparation for eventual transplantation into patients, we will explore biomatrices as supports for these cells and also approaches to suppressing the inflammatory response to increase the chances of graft survival.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MAX IV Laboratory, Lund University
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 485 792
Administrative Contact
Stefan Jovinge (Prof.)

Participants (6)

INSTITUT PASTEUR
France
EU contribution
€ 306 840
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Ms.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 341 400
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernd K. Fleischmann (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 551 760,14
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lynne Hughson (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 285 240
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 78 570,86
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Anne-Marie Coriat (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 650 397
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael G Robinson (Mr.)