Objective
Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question remains whether specific targets or mechanisms involved in mitochondrial dysfunction will be amenable to therapeutic intervention. MitoTarget is an ambitious project aimed at providing solid data to better understand and exploit the circumstantial evidence linking mitochondrial dysfunction with neuronal dysfunction culminating in neurodegenerative disease. A 36 months translational research program will bring together a unique partnership between basic scientists, a seasoned team of clinical investigators and a SME that has identified a first-in-class compound, TRO19622, that targets mitochondria and has powerful neuroprotective and neuroregenerative activities. In parallel, and orchestrated by the SME that is the coordinator of the project, MitoTarget will bring together a more comprehensive insight into the mechanisms leading to mitochondrial impairments and establish their clinical relevance in a severe orphan neurodegenerative disease, ALS. If successful, it is expected that from this proof of principle a new class of therapeutic agents targeting the underlying mitochondrial dysfunction in neurons or their supporting cells will emerge. Results of the project have the potential to create a new paradigm for the drug discovery for neurodegenerative diseases.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesbasic medicinepathology
- medical and health sciencesbasic medicineneurologyparkinson
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
Keywords
Call for proposal
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
13288 MARSEILLE CEDEX 9
France
See on map
Participants (17)
S10 2TN Sheffield
See on map
72074 Tuebingen
See on map
60323 Frankfurt Am Main
See on map
75012 Paris
See on map
06003 Nice
See on map
10117 Berlin
See on map
30625 Hannover
See on map
WC2R 2LS London
See on map
3000 Leuven
See on map
Participation ended
3584 CX Utrecht
See on map
34000 Montpellier
See on map
6108 Halle
See on map
59037 Lille
See on map
87000 Limoges
See on map
89081 Ulm
See on map
69002 Lyon
See on map
13284 Marseille
See on map