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Development of 6-mercaptopurine and Methotrexate oral liquid formulations for the maintenance treatment of Acute Lymphoblastic Leukæmia in children

Objective

Only for Children Pharmaceuticals, a French based Small and Medium-sized Enterprise (SME) developing drug for children, is the Coordinator of a multinational, multidisciplinary and complementary Consortium. This Consortium is composed of highly qualified organizations and notorious clinicians in pediatric hemato-oncology. The Consortium is an integrated team of competencies (clinicians, pædiatricians, pharmacokineticists, pharmacists, manufacturers, engineers, regulatory and ethical experts) capable of executing a pædiatric drug development from its designing to market. The Consortium will perform the non-clinical development of Methotrexate (MTX) and the non-clinical and clinical development of 6-Mercaptopurine (6MP) oral liquid formulations adapted for maintenance treatment of pediatric acute lymphoblastic leukemia with the crucial objective to make available these adapted formulation by 2012 at the latest. Methotrexate and 6-mercaptopurine are on the EMEA Priority list of off-patent medicinal products of paediatric working party of the European medicine agency - June 2007. On September 2007, EMEA’s COMP Committee has granted the orphan status to Methotrexate (oral liquid) and 6-mercaptopurine (oral liquid).

Field of science

  • /medical and health sciences/clinical medicine/oncology/leukemia

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
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Coordinator

Only For Children Pharmaceuticals
Address
Rue Henri Barbusse 35 Bis
75005 Paris
France
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 440 678,70
Administrative Contact
Vincent Grek (Dr.)

Participants (11)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 185 214
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Prof.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 259 941,60
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kjeld Schmiegelow (Prof.)
Laboratoire Philippe Davioud
France
EU contribution
€ 308 499,60
Address
Derrière Les Jardins 2A
27570 Tillières Sur Avre
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Davioud (Dr.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 110 400
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Uwe Droste (Mr.)
FRANCE EUROPE INNOVATION
France
EU contribution
€ 186 091,20
Address
Rue Des Renaudes 32
75017 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olivier Degrand (Mr.)
PharmaFlow Ltd

Participation ended

Ireland
EU contribution
€ 69 873,50
Address
Lisbunny Industrial Estate
Co Tipperary
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Finbarr Cremin (Mr.)
Cardinal Systems
France
EU contribution
€ 535 530
Address
Avenue De La République 91
Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Grégoire Lacroix (Mr.)
HOSPICES CIVILS DE LYON
France
EU contribution
€ 54 000
Address
Quai Des Celestins 3
69002 Lyon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Cecile Legros (Ms.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 72 000
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Neufeldt (Ms.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
EU contribution
€ 46 291
Address
Allee De L'ile Gloriette 5
44093 Nantes
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Brethet (Ms.)
CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France
EU contribution
€ 47 895,40
Address
Avenue Oscar Lambret 2
59037 Lille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Florence Nosal (Ms.)