Objective To address the question of how intracellular pathogens modulate phagosome trafficking in the host cell we propose to use a systems biology approach, using an iterative cycle of experimental data, model, new experimental data, improved model. The ultimate aim of our project is to develop a mathematical model of mycobacteria and Salmonella infection of macrophages that can be applied to find new interventions that promote clearance of intracellular bacteria by phagocytic cells, and so boost innate immunity. To answer this question we have assembled a consortium of European experts able to tackle complementary aspects of this problem. By bringing together these laboratories to focus on a common goal we will be able to lever their expertise far beyond the state of the art. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesmathematicsapplied mathematicsmathematical model Keywords Intracellular bacterial pathogens ODEs Salmonella machine learning mycobacteria phagocytosis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE EU contribution € 595 158,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 566 600,00 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Guillaine De Blécourt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 509 720,00 Address PLESMANLAAN 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 868 272,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Birgit Knepper-Nicolai (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT JOZEF STEFAN Slovenia EU contribution € 450 625,00 Address Jamova 39 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Research Organisations Administrative Contact Darko Korbar (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data