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Molecular mechanisms of neuronal restoration: novel approaches for Parkinson's Disease

Objective

MOLPARK aims to define the basic cellular and molecular mechanisms underlying the generation, differentiation, survival and connectivity of nigrostriatal dopaminergic neurons and translate this knowledge into radically new therapeutic strategies for Parkinson's disease (PD). MOLPARK brings together two industrial partners and 6 world-renowned academic groups with a uniquely advantageous knowledge platform based on complementary state-of-the-art technologies and recent relevant discoveries in their laboratories. These include, unique approaches for stem cell renewal control based on novel insights into the function of GABA receptors and intracellular signaling components such as Bex1, novel neurotrophic factors for dopaminergic neurons such as CDNF and MANF, novel approaches to harness the power of GDNF and Wnt proteins for stimulating the growth of dopaminergic terminals and novel ways to enhance synaptogenesis, MOLPARK’s strategy is based on four major interrelated objectives. I). Define the mechanisms of stem cell self-renewal, differentiation and integration and exploit these mechanisms to induce or boost existing self-repair processes with the aim of replenishing neurons in PD. 2). Define the mechanisms for sustaining dopaminergic neuron survival in health and disease with the aim of developing new, effective growth factor-based therapies aimed at protecting neurons in PD. 3). Define the mechanisms that promote the growth of DA nigrostriatal axons and dendrites with the aim of identifying therapeutic strategies based on restoring neural processes in PD. 4). Define the mechanisms that promote and sustain the synaptic connections of dopaminergic neurons with the aim of restoring connections in PD.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/neurology/parkinson
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CARDIFF UNIVERSITY
Address
Newport Road 30-36
CF24 ODE Cardiff
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 636 163
Administrative Contact
Nick Bodycombe (Mr.)

Participants (6)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 035 517
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Tegelberg (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 388 162
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Angelika Haefeker (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 388 162
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna-Maija Miettinen (Dr.)
University College London
United Kingdom
EU contribution
€ 517 760
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
ACTAR AB
Sweden
EU contribution
€ 253 444
Address
Nobels Vaeg 3
171 77 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Montgomerie (Ms.)
CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY
Finland
EU contribution
€ 253 445
Address
Microkatu 1
70210 Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kirsi Pohjolainen (Ms.)