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Confronting the clinical relevance of biocide induced antibiotic resistance

Objective

Biocides have been in use for hundreds of years for antisepsis, disinfection and preservation. Despite this widespread and ever increasing use most bacterial and fungal species remain susceptible to biocides. The dramatic increase and spread of resistance to antibiotics linked to reports of co- and cross-resistance between antibiotics and biocides raised speculations on potential hazard of biocide use. The overarching question which BIOHYPO is aimed to address is: has the use of biocides contributed to the development and spread of clinically significant antibiotic resistance in human pathogens? Core of BIOHYPO are a high throughput screening approach on collections of thousands of well characterized microorganisms and an interactive web based data analysis platform. Phenotypic screening for reduced susceptibility to biocides, detection of novel resistance genes and mobile elements, and screening for their molecular epidemiology and metagenomics will be accompanied by methodological innovation for testing, risk evaluation and registration of biocides. Altogether BIOHYPO aims to provide solid data and analysis to direct future issuing of guidelines for safe environmental, medical and industrial use of biocides.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /medical and health sciences/health sciences/epidemiology
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI SIENA
Address
Via Banchi Di Sotto 55
53100 Siena
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 473 856
Administrative Contact
Silvano Focardi (Prof.)

Participants (12)

QUOTIENT BIORESEARCH
United Kingdom
EU contribution
€ 280 200
Address
Newmarket Road
CB7 5WW Fordham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Rodgers (Dr.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 274 716
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
INESC ID - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA
Portugal
EU contribution
€ 271 824
Address
Rua Alves Redol 9
1000 029 Lisboa
Activity type
Research Organisations
Administrative Contact
Arlindo Oliveira (Prof.)
MIDDLE EAST TECHNICAL UNIVERSITY
Turkey
EU contribution
€ 193 200
Address
Dumlupinar Bulvari 1
06800 Ankara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulku Yetis (Prof.)
Lysoform Dr. Hans Rosemann GmbH
Germany
EU contribution
€ 100 200
Address
Kaiser-wilhelm-strasse 133
12247 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans-Joachim Roedger (Dr.)
BIOLAB ESPAÑOLA DE ANÁLISIS E INVESTIGACIÓN SL
Spain
EU contribution
€ 223 600
Address
Parc Cientific De Barcelona, Calle Baldiri Reixac 4-6
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luca Salvi (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 279 945
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad Ruiz (Mr.)
GAZI UNIVERSITESI
Turkey
EU contribution
€ 218 398
Address
Gazi Universitesi Rektorlugu Projeler Koordinasyon Merkezi
06500 Ankara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riza Ayhan (Prof.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 217 866
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margherita Pasetti (Ms.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 218 400
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Leib (Prof.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 180 000
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luciana Giovannetti (Prof.)
AAT-ADVANCED ANALYTICAL TECHNOLOGIES
Italy
EU contribution
€ 67 500
Address
Via Martiri Della Resistenza-galleria San Giuseppe 1
29100 Piacenza
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marina Elli (Dr.)