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Single molecules in soft matter: dynamical heterogeneity in supercooled liquids and glasses

Objective

Single-molecule optical microscopy provides average-free, dynamical and structural information about condensed matter at molecular scales. Single fluorescent molecules can now be located and tracked with a spatial resolution as high as a few tens of nanometers, even at depths as large as several microns. These capabilities are ideal to link the macroscopic physical properties of soft condensed matter with the structure, organization and dynamics of the constituent molecules. Perhaps the most surprising conclusion drawn from single-molecule observations is the unsuspected heterogeneity of molecular assemblies, both in time and space, which had remained largely hidden in conventional ensemble experiments. The structural glass transition is said to be one of the hardest open problems in condensed matter science. Although most agree on the crucial part played by heterogeneity in this process, the guesses vary wildly as to the scale and relaxation times of the inhomogeneities. Our recent discovery of glassy rheology in supercooled glass formers, following earlier observations of heterogeneity, has been received with much interest in the complex liquids community. I am convinced that single-molecule studies have the potential to radically change our view of supercooled liquids and glasses. In a broader sense, molecular insight from chemical physics complements the general ideas developed by statistical physicists. I believe it is the missing link toward a molecular control of the physical properties of soft materials. I propose to perform a broad range of novel single-molecule experiments using a micro-rheological cell to apply mechanical stress, strains and/or temperature jumps. In particular, we will perform mechanical studies of solid-solid friction, and temperature-jump studies of single proteins and single protein complexes.

Field of science

  • /natural sciences/physical sciences/condensed matter physics/soft matter physics

Call for proposal

ERC-2008-AdG
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

UNIVERSITEIT LEIDEN
Address
Rapenburg 70
2311 EZ Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 836 000
Principal investigator
Michel Orrit (Prof.)
Administrative Contact
Ton Brouwer (Mr.)

Beneficiaries (1)

UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 1 836 000
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Principal investigator
Michel Orrit (Prof.)
Administrative Contact
Ton Brouwer (Mr.)