Skip to main content

Servicing the European Biomedical Research Community: Archiving and Dissemination of Mouse Models of Human Disease

Objective

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:

1) Develop a series of mutant alleles for every gene in the mouse genome
2) Determine the phenotypic consequences of each mutation
3) Identify mouse models for the complete disease spectrum in humans

To exploit this emerging resource, mouse models must be preserved and made available to the European biomedical research community. Building on EMMA's previous achievements as the primary mouse repository in Europe, EMMAservice aims to meet the future challenges presented by archiving and disseminating mouse models in the ERA as follows:

- Archiving of 1224 new mouse mutant lines in support of individual depositors and also European mouse genetics programmes
- Support of eligible customers with free of charge Transnational Access for up to 20% of requested mouse resources.
- Technology development will underpin the archiving and distribution efforts by advancing current sperm freezing technology
- Training courses will promote the shipment of frozen germplasm rather than live mice
- EMMA informatics will support user services by setting new standards for user friendly accession of EMMA services, extensive data curation and cross referencing with other mouse database resources
- Outreach efforts to attract users will be widened and addressed at the translational research community

EMMAservice will contribute significantly to the development of a world leading repository and European capacity in mouse disease model archiving and distribution, supporting the needs of the wider European biomedical research community. The emerging mouse mutant and associated data resources will offer the opportunity to decipher molecular disease mechanisms and may, in some instances, provide the foundation for the development of diagnostic, prognostic and therapeutic strategies.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /social sciences/sociology/governance/public services

Call for proposal

FP7-INFRASTRUCTURES-2008-1
See other projects for this call

Funding Scheme

CP-CSA-Infra - Combination of CP and CSA

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 786 894,46
Administrative Contact
Glauco Tocchini-Valentini (Prof.)

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 258 199,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Josette Roger (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 1 048 622,75
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Hilary Gates (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 306 008
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riitta Ljungström (Ms.)
FUNDACAO CALOUSTE GULBENKIAN
Portugal
EU contribution
€ 452 490
Address
Avenida Berna 45
1000 Lisboa
Activity type
Research Organisations
Administrative Contact
Jose Mario Leite (Dr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 1 591 113,55
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 650 559,60
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 552 600,80
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Katell Schaeffer (Ms.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 672 411,59
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Neil Davison (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 681 099,65
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Maria Del Mar Garcia (Ms.)