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Development of a Spatio-Temporal-Energetic Radiation Research Platform for Animals

Objective

In modern radiotherapy complex radiation fields are applied on cancer patients to eradicate cancer cells, while sparing the surrounding healthy tissue. In stark contrast, irradiation systems for small animals bear almost no resemblance to this paradigm. Usually these systems only administer large radiation fields which can not be modulated in their spatio-temporal aspect. Consequently, many animal radiation experiments have little relevance for human radiotherapy. To allow studies of radiation effects on tumors and healthy tissues in small animals and the synergistic effects of radiation and other treatment modalities (chemotherapy, gene therapy) it engineering of the next generation of animal irradiation devices is needed now. In this proposal we describe the development of a versatile small animal irradiation device capable of delivering precise radiation fields with modulation of the spatio-temporal-energetic aspects. A dynamic applicator for a kilovolt x-ray device will mimic the delivery of modern human radiotherapy. In addition, energy modulation of the radiation beams will allow studies with dose enhancing agents such as gold particles. A treatment planning system will be devised, based on Monte Carlo simulations, which will take tissue heterogeneities into account. A conversion of small animal tomographic images into accurate geometries needed for the Monte Carlo dose calculations will be developed. An on-board cone-beam tomographic imager will be implemented to enable the acquisition of 3D images during radiation treatment, again mimicking the state of the art in human radiotherapy. The image-guided small animal radiation system, with unprecedented accuracy and versatility in its spatio-temporal-energetic radiation patterns, combined with integrated real-time imaging capabilities, will facilitate uncovering a wealth of data relevant for radiation oncology and radiobiology.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/mathematics/pure mathematics/geometry
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/physical sciences/theoretical physics/particles
  • /medical and health sciences/clinical medicine/oncology

Call for proposal

FP7-PEOPLE-IRG-2008
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Address
Dr. Tanslaan 12
6229 ET Maastricht
Netherlands
Activity type
Research Organisations
EU contribution
€ 100 000
Administrative Contact
Floor Franssen (Ms.)