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Novel strategies for the prevention and control of persistent infections

Objective

Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infected subjects. Globally, there are more than 14 million persons dually infected with TB and HIV. Drug resistance to HIV-treatment and appearance of multiple-drug resistance (MDR) and off late of Extra-Drug Resistance (XDR) strains of M. tuberculosis , the causative agent of human TB is steadily leading to a hopeless situation as far as therapy is concerned. To make things worse, there is no effective vaccine available against the persistent infections addresses in this proposal. The four SME members of this consortium with complimentary areas of research and business activities, LIONEX (in TB), Prionics (in ParaTB) , Vichem (in HIV) and IVD (in pig infections) are dedicated to solving the problems of the persistent infections mentioned above by employing novel strategies of product development for diagnosis, prevention and control of these global diseases by outsourcing demanding but feasible work to internationally known research organisations (RTDP) with highly positive track record. The SMEs alone cannot perform the outsourced work but shall validate and exploit the results provided by the RTDPs. Our novel but realistic objectives are: 1. To develop new drug candidates for drug resistant persistent infections (HIV and TB) 2. To identify and isolate novel antigens for the diagnosis of TB, ParaTB and infections in pigs 3. To identify antigens suitable for vaccine development for these persistent infections 4. To develop marketable, improved diagnostic products within a period of three years

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /social sciences/economics and business
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-SME-2008-1
See other projects for this call

Funding Scheme

BSG-SME - Research for SMEs

Coordinator

LIONEX GMBH
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 533 984
Administrative Contact
Mahavir Singh (Prof.)

Participants (11)

VICHEM CHEMIE KUTATO KFT
Hungary
EU contribution
€ 100 410
Address
Hermann Otto Utca 15
1022 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
György Kéri (Prof.)
PRIONICS AG
Switzerland
EU contribution
€ 359 000
Address
Wagistrasse 27 A
8952 Schlieren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alex Raeber (Dr.)
IVD GESELLSCHAFT FUR INNOVATIVE VETERINARDIAGNOSTIK GMBH
Germany
EU contribution
€ 276 700
Address
Heisterbergallee 12
30453 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerald-F. Gerlach (Prof.)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 8 160
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Strätz (Dr.)
Food and Environment Research Agency
United Kingdom
EU contribution
€ 11 200
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lucinda Cranham (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 9 200
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jill Blomstrand (Ms.)
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 4 440
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Administrative Contact
Pere-Joan Cardona Iglesias (Prof.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 5 696
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sergio Romagnani (Prof.)
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 11 200
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jozef Van Lint (Mr.)
TECHNISCHE UNIVERSITAT CLAUSTHAL
Germany
Address
Adolph Romer Strasse 2A
38678 Clausthal Zellerfeld
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Heike Schroeder (Dr.)
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Joppe (Mr.)