Objective The essence of the proposal is the fabrication of multiple nano containers which exhibit double and triple stimuli response and site recognition. Specifically, the containers will be grafted by Leuprolide (LP) for prostate cancer recognition. Multiple containers will be filled by two drugs (e.g. LP and DOX) in different compartments not interacting with each other chemically (cocktail of drugs, e.g. Container1 Leuprolide (LP) and Container2 Doxorubicin (DOX)). The release can be excited by internal or external stimuli response. The internal stimuli response of our nanocontainers will require simultaneous recognition of pH, redox and/or T of the tumour. The external induction will be caused by RF excitation (hyperthermia). The nanocontainers will identify the tumour first by the agonist (LP). After trapping the container at the tumour, they will be activated by the double and triple internal excitation. This way, we achieve extremely local chemotherapy of the diseased site and the healthy organs will be untouched. Our smart nanocontainers will be tuned for prostate cancer, but our system will be evaluated for other cases such as breast cancer and thrombosis. The containers will be modified (phase transition, volume change, degradation, etc.) and deliver the drug only and if only the two sensors give positive response. The containers can be excited by external induction (Radio Frequency (hyperthermia) RF or laser light). This revolutionary strategy is necessary because the externally induced delivery methods have the disadvantage that the radiofrequency fields, the magnetic fields and the laser lights are not local but they extend over large space, larger than the size of the tumour. One cannot focus from outside the laser beam directly to the tumour only may be due to lack of imaging facilities. Our technology will prevent the release of drugs in sites where the local values correspond to the healthy tissue. Fields of science medical and health sciencesclinical medicineoncologyprostate cancerengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsradio technologyradio frequencymedical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesphysical sciencesopticslaser physics Keywords delivery drug nanocontainers Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Call for proposal ERC-2008-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EU contribution € 2 000 000,00 Address END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET 15341 Agia Paraskevi Greece See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Research Organisations Principal investigator George Kordas (Prof.) Administrative Contact Euripides Papadopoulos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Greece EU contribution € 2 000 000,00 Address END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET 15341 Agia Paraskevi See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Research Organisations Principal investigator George Kordas (Prof.) Administrative Contact Euripides Papadopoulos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
