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Multicomponent Radiochemical reactions

Objective

The main focus of this research proposal is to diversify the portfolio of radiochemical reactions for the production of known and new 18F-radiotracers. The strategy we propose to investigate is based on the use of readily available 18F-labelled building blocks in the context of multicomponent reactions. This approach has the potential to deliver 18F-radiotracers not amenable to direct 18F-labelling due to poor reactivity or he unavailability of suitable reaction conditions. The project therefore concerns the development of various two-step synthetic sequences for the preparation of architecturally complex 18F-radiolabelled tracers applying sequences that will combine a nucleophilic 18F-fluorination process with a multicomponent reaction involving an 18F-labelled building block. The application of this unprecedented approach to the synthesis of radioactive biomarkers which are notoriously difficult to label by conventional methods will be investigated. This project will advance radiochemistry for molecular imaging and therefore indirectly contribute to improve human health.

Field of science

  • /natural sciences/chemical sciences/nuclear chemistry/radiochemistry

Call for proposal

FP7-PEOPLE-IIF-2008
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 177 948,70
Administrative Contact
Linda Polik (Ms.)