Role of protein-tyrosine phosphatases in angiogenesis

Informations projet

PTPS IN ANGIOGENESIS

N° de convention de subvention: 237425

Projet clôturé

Date de début 1 Juillet 2009

Date de fin 30 Juin 2011

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total Aucune donnée

Contribution de l’UE € 180 801,44

Coordonné par

Novartis Forschungsstiftung
Suisse

Objectif

Angiogenesis is the formation of new blood vessels from pre-existing ones and is involved in different physiological and pathological processes such as cancer and ischemia. Tyrosine phosphorylation is a reversible process, mediated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). Although the role of PTKs in angiogenesis is well established, little is known about the function of specific PTPs in this process. In collaboration with Dr. H. Augustin, (Heidelberg, Germany) we found that the expression of several PTPs changes when spheroids of endothelial cells embedded in 3D matrices are exposed to angiogenic stimuli. To investigate the role of PTPs in angiogenesis, we generated a tetracycline-inducible shRNA library for targeting PTPs. We are also generating lentiviral vectors expressing inducible cDNAs of all the human PTPs. I propose to investigate the biological role of PTPs in angiogenesis by loss- and gain of function experiments in endothelial cells, using different in vitro and in vivo angiogenesis assays. My studies will determine the role of PTPs in developmental and pathological angiogenesis and test their merits as targets of angiogenic therapy.

Champ scientifique (EuroSciVoc)

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• sciences médicales et de la santé › médecine clinique › oncologie

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Mots‑clés

• Angiogenesis
• Endothelial Cells
• PTPs
• Signaling

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development"

Appel à propositions

FP7-PEOPLE-IEF-2008
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Régime de financement

MC-IEF -

Coordinateur

Novartis Forschungsstiftung

• Contribution de l’UE: € 180 801,44
• Adresse: Maulbeerstrasse 66 ; 4058 BASEL ; Suisse
• Type d’activité: Organismes de recherche
• Coût total: Aucune donnée