Objetivo Salicylate is an important signal compound in plants connected with resistance against viral and fungal infections. Little is known about the metabolic changes involved with the induction of resistance by salicylate. Metabolomics offers a novel tool to study these changes and will be helpful in increasing our understanding of the resistance mechanisms.For this study we will use tobacco plants over-expressing microbial genes involved in the salicylate biosynthesis (patented from the host laboratory), TMV-infected plants and wild-type plants. NMR spectrometry will be used as tool to measure overall changes in the metabolome.Eventually targeted metabolomic tools such as LC-MS, GC-MS and MS-MS will be used for a more detailed targeted metabolic profiling. This systems biology approach will help us to identify (secondary) metabolite pathways involved in resistance. Ámbito científico ciencias médicas y de la saludciencias de la saludenfermedad infecciosa Palabras clave Metabolomics plant resistance salicylate Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2004-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador LEIDEN UNIVERSITY Dirección Rapenburg 70 Leiden Países Bajos Ver en el mapa Enlaces Sitio web Opens in new window Aportación de la UE Sin datos
