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Cerebellar-Cortical Control: Cells, Circuits, Computation, and Clinic

Objective

A functional understanding of the cerebellum, the structure of the human brain with the most neurons, requires the combined effort of scientists working from the cellular level up to the behavioural level, and it requires scientists trained to cross these levels. The C7 network brings together 9 research groups to form a European institute for the interdisciplinary study of the cerebellum. The network will provide a unique multi-disciplinary training experience for young researchers in systems neuroscience. We are joined by 5 industrial partners who will help to realize important technological innovations and the commercial potential by developing cutting-edge technology for research and clinical applications. With a combination of electrophysiology, behavioural and clinical research, computational modelling and neuroimaging we will aim to answer three important questions: a) What is the computation performed in cerebellar networks? We will provide a multi-level description of the basic cerebellar computational unit, the micro-column. b) How do distributed synaptic changes lead to learning? We link structure to function through an intense program of experimentation and modelling on the fast adaptation of motor behaviour thought by many to be the main function of the cerebellum. c) How do the closed loops between the cerebellum and neocortex generate motor control and cognition? Multi-site recordings, TMS and clinical studies will reveal the previously unexplored interaction between cerebellum and related structures. C7 includes two clinical research centres and two patient organizations, promoting the transfer of insights from basic science to clinical practice. In particular, we will explore brain compensation following cerebellar dysfunction using genetic mouse models and TMS. In sum, C7 will provide the interdisciplinary training environment necessary for a new understanding of the cerebellum.

Field of science

  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

University College London
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 772 373
Administrative Contact
Joern Diedrichsen (Dr.)

Participants (8)

BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 341 882
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dori Schneider (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 427 571
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten Anthonie Frens (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 394 407
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans-Peter Thier (Prof.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 399 526
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dagmar Timmann (Prof.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 394 169,50
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erik De Schutter (Prof.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 415 205
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
R Christopher Miall (Prof.)
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 423 150
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other
Administrative Contact
Christiaan Innocentius De Zeeuw (Prof.)
Alpha Omega Engineering Ltd.
Israel
EU contribution
€ 94 386
Address
Ha Avoda 3
17105 Nazareth Illit
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Imad Younis (Mr.)