Objective
Sulfate-reducing bacteria (SRB) are anaerobic prokaryotes characterized by sulfate-reduction into hydrogen sulfide as the major component of their metabolic process. Recently the vision of sulfate-reduction as a strict anaerobic process has changed, since SRB have been isolated from environments where oxygen is present. These SRB possess an arsenal of protection systems against the toxic effect of oxygen such as detoxification systems and oxygen reducing enzymes. SRB are very intriguing for ecological point of view; moreover, their metabolic diversity has been used in industry for bioremediation processes. SRB are able to reduce oxidized highly toxic heavy metals, such as uranium or chromate, in less soluble and less toxic forms. Regarding the great interest that SRB represent for ecologist and industrial, we need to get more insights into adaptive mechanisms of SRB to oxidative stress conditions. A better understanding of these mechanisms would help in optimizing use of these bacteria in biotechnological applications. While most of the studies have been performed using cDNA microarrays and proteomics analysis, we propose to analyze SRB response to oxidative stress by metabonomic approach, using Desulfovibrio vulgaris Hildenborough as model organism. This new approach would lead to identify and quantify metabolites changes in response to cells exposure to oxidative conditions, generated either by oxygen or heavy metals. Metabolites identification and quantification will be performed by combining both NMR and LC-Mass spectrometry. Related with proteome modifications, it would first help understanding changes observed at the genomic level and provide novel insights into the effect of oxidative stress conditions on anaerobic metabolism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- engineering and technology environmental biotechnology bioremediation
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.