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Experience-dependent modifications of developing neural circuits and animal behaviours

Objective

"During development, neuronal connectivity is initially established by genetically determined intrinsic factors, e.g. molecular cues and spontaneous activity, generating networks according to a ""best guess"" strategy. However, with the appearance of sensory organs, external inputs will refine these connections, allowing adaptation to the environment. In the Xenopus developing visual system, repetitive moving visual stimuli induce long lasting changes in the direction-sensitivity of some tectal neurons, apparently via modification of synaptic strength. However, it is still unknown how this synaptic plasticity contributes to the refinement of neural circuits for precise information processing and adjustment of animal’s behaviours. Using a multidisciplinary approach combining cutting-edge genetic engineering methods to monitor and manipulate activity of specific neurons or entire circuits, development of novel mathematical and computational methods and kinematic analyses of motor behaviours, I will investigate how sensory visual experience may affect the activity and interaction of the optic tectum neuronal circuit and motor behaviour. These experiments will contribute to our understanding of the role of sensory experience in shaping the development of neural circuits and animal behaviour. They will also shed light into the mechanisms by which the nervous system self wires, adapts, and learns. The study of these mechanisms might contribute to the design of new therapeutic treatments for developmental disorders associated with impaired nerve connections."

Field of science

  • /natural sciences/computer and information sciences/data science/data processing
  • /medical and health sciences/medical biotechnology/genetic engineering

Call for proposal

FP7-PEOPLE-IRG-2008
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 100 000
Administrative Contact
Marie-Pascale Martel (Ms.)