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Predicting antibiotic resistance

Objective

The aim of this proposal is to describe and predict the dynamics of antibiotic resistance development at the level of the drug target, the microbe and the host. That is, we want to generate the knowledge required to be able to connect resistance mechanism --> bacterial physiology and fitness --> bacterial survival within a host --> bacterial spread between hosts. To achieve this goal we will develop quantitative models that can capture these complex dynamics, obtain relevant parameter values and validate the models by testing them in suitable in vitro, animal models and in clinical settings. We will address three main areas (A-C) in 11 different work packages. A. Formation and emergence of resistant bacteria (WPs1-5). The rate of formation of resistant mutants is one major determinant that influences how rapidly resistant mutants will appear in response to antibiotic use. Depending on the type of resistance mechanism factors such as rates of mutation, recombination and transfer of plasmids will be important. In WPs 1-5 we will experimentally determine these rates for different combinations of bacterial species and resistance mechanisms. B. Survival and persistence of resistant strains (WPs 6-8). A key factor that affects the survival and persistence of resistant strains is the impact the particular resistance mechanism has on bacterial physiology, including bacterial growth rate and virulence. We want to determine the effect of various drug resistance mechanisms on cellular physiology and fitness to establish a link between the molecular alteration and potential effects at the cellular level. C. Transmission of resistant strains (WPs 9-11). Finally we want to understand and predict how resistance mechanisms (by their effect on bacterial physiology) influence the ability of the bacteria to be transmitted between hosts. Thus, we aim to generate both animal and clinical determinations of how resistance affects transmissibility and testable mathematical models.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /medical and health sciences/basic medicine/physiology

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UPPSALA UNIVERSITET
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 400 000
Administrative Contact
Marianne Wigenius (Ms.)

Participants (11)

STATENS SERUM INSTITUT
Denmark
EU contribution
€ 350 000
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Administrative Contact
Niels Frimodt-Møller (Prof.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 500 000
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
José Ignacio Flores Nicolás (Mr.)
University College London

Participation ended

United Kingdom
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 850 000
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad-Ruiz (Mr.)
University of Zurich
Switzerland
EU contribution
€ 550 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erik Christian Böttger (Prof.)
INSTITUT PASTEUR
France
EU contribution
€ 500 000
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 350 000
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ian Chopra (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 350 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Annick Bertault (Ms.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 450 000
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nick Bodycombe (Mr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 350 000
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tracey Swift (Dr.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom
EU contribution
€ 350 000
Address
North Street 66 College Gate
KY16 9AJ St Andrews
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Trish Starrs (Ms.)