Objective
The present proposal represents an effort in the search for new tools for the speciation analysis of bio-inorganic molecules (BIM), particularly containing Se and Hg. The project is aimed at the evaluation of the importance of Se and Hg-containing proteins in toxicological responses to essential (Se) and toxic (Hg) elements as well as the interferences due to heavy metals exposure on the metabolism of essential elements in the human body. This will be achieved by the development of new multidimensional analytical approaches that allow the identification, characterization and determination of the species involved with a special emphasis on BIM.
The project will be carried out by interfacing high performance liquid chromatography (HPLC) with element specific detectors such as inductively coupled plasma mass spectrometry (ICP-MS). The use of both Sector Field and Quadrupole based mass filters will be exploited. Several approaches, including speciated isotope dilution mass spectrometric (SIDMS) techniques for the accurate determination of the species and electrospray (ES-MS) mass spectrometry for the identification and characterization of the protein content will be developed and applied. The correlation of the speciation results, with the level of metal exposure will be used to study the possible implications of the presence of metalloproteins for biomonitoring and toxicological purposes in humans.
The integration of approaches typically used in molecular biology for the speciation studies by coupling them to elemental mass spectrometry will allow a better elucidation of the role of the BIMspecies identified by the use of multidimensional analytical techniques in the various and "compartments" of the human body.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROME
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.