Objective
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.
Fields of science
Call for proposal
FP7-HEALTH-2009-two-stage
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
08003 Barcelona
Spain
See on map
Participants (13)
80539 Munchen
See on map
W1B 1AL London
See on map
75794 Paris
See on map
8092 Zuerich
See on map
02 106 Warszawa
See on map
16610 Praha 6
See on map
69117 Heidelberg
See on map
13100 Vercelli
See on map
08028 Barcelona
See on map
38126 Braunschweig
See on map
10117 Berlin
See on map
6708 PB Wageningen
See on map
3000 Leuven
See on map