Objective
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2009-two-stage
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.