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Systems biology of Mycobacterium tuberculosis

Objective

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.

Field of science

  • /medical and health sciences/clinical medicine/pneumology/tuberculosis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/physiology

Call for proposal

FP7-HEALTH-2009-two-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 1 528 837
Administrative Contact
Michela Bertero (Dr.)

Participants (13)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 034 185
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Birgit Gieding (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 895 544
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
John Wills (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 688 948
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Patrick Mounaud (Mr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 1 345 851
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudolf Aebersold (Prof.)
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 643 110
Address
Pawinskiego 5A
02 106 Warszawa
Activity type
Research Organisations
Administrative Contact
Agata Rogowska (Ms.)
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Czechia
EU contribution
€ 485 521
Address
Flemingovo Nam. 542/2
16610 Praha 6
Activity type
Research Organisations
Administrative Contact
Renata Sroglova (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 308 514
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Ivanka Araujo (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 369 600
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carlo Muzio (Dr.)
OMNIA MOLECULAR S.L.
Spain
EU contribution
€ 460 000
Address
Calle Josep Samitier - Parc Cientific De Barcelona 1-5
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maurici Torra Juanola (Mr.)
LIONEX GMBH
Germany
EU contribution
€ 479 240
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mahavir Singh (Prof.)
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 467 100
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Brigitte Lehmann (Dr.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 748 151
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jos Teunissen
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 108 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karolien Mariën (Mrs.)