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Systems biology of Mycobacterium tuberculosis

Obiettivo

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.

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Coordinatore

FUNDACIO CENTRE DE REGULACIO GENOMICA
Indirizzo
Carrer Doctor Aiguader 88
08003 Barcelona
Spagna
Tipo di attività
Research Organisations
Contributo UE
€ 1 528 837
Contatto amministrativo
Michela Bertero (Dr.)

Partecipanti (13)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germania
Contributo UE
€ 1 034 185
Indirizzo
Hofgartenstrasse 8
80539 Munchen
Tipo di attività
Research Organisations
Contatto amministrativo
Birgit Gieding (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
Contributo UE
€ 895 544
Indirizzo
North Star Avenue Polaris House
SN2 1FL Swindon
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contatto amministrativo
John Wills (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Contributo UE
€ 688 948
Indirizzo
Rue Michel Ange 3
75794 Paris
Tipo di attività
Research Organisations
Contatto amministrativo
Patrick Mounaud (Mr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Svizzera
Contributo UE
€ 1 345 851
Indirizzo
Raemistrasse 101
8092 Zuerich
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Rudolf Aebersold (Prof.)
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK
Polonia
Contributo UE
€ 643 110
Indirizzo
Pawinskiego 5A
02 106 Warszawa
Tipo di attività
Research Organisations
Contatto amministrativo
Agata Rogowska (Ms.)
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Cechia
Contributo UE
€ 485 521
Indirizzo
Flemingovo Nam. 542/2
16610 Praha 6
Tipo di attività
Research Organisations
Contatto amministrativo
Renata Sroglova (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germania
Contributo UE
€ 1 308 514
Indirizzo
Meyerhofstrasse 1
69117 Heidelberg
Tipo di attività
Research Organisations
Contatto amministrativo
Ivanka Araujo (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italia
Contributo UE
€ 369 600
Indirizzo
Duomo 6
13100 Vercelli
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Carlo Muzio (Dr.)
OMNIA MOLECULAR S.L.
Spagna
Contributo UE
€ 460 000
Indirizzo
Calle Josep Samitier - Parc Cientific De Barcelona 1-5
08028 Barcelona
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Maurici Torra Juanola (Mr.)
LIONEX GMBH
Germania
Contributo UE
€ 479 240
Indirizzo
Salzdahlumer Strasse 196
38126 Braunschweig
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Mahavir Singh (Prof.)
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germania
Contributo UE
€ 467 100
Indirizzo
Unter Den Linden 6
10117 Berlin
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Brigitte Lehmann (Dr.)
WAGENINGEN UNIVERSITY
Paesi Bassi
Contributo UE
€ 748 151
Indirizzo
Droevendaalsesteeg 4
6708 PB Wageningen
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jos Teunissen
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgio
Contributo UE
€ 108 000
Indirizzo
Oude Markt 13
3000 Leuven
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Karolien Mariën (Mrs.)