Systems biology of Mycobacterium tuberculosis

Obiettivo

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.

Campo scientifico

• scienze naturali › scienze biologiche › biochimica › biomolecole › proteine › proteomica
• scienze mediche e della salute › medicina clinica › pneumologia › tubercolosi
• scienze mediche e della salute › medicina di base › fisiologia

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH-2009-2.1.2-1 - Systems biology approaches for basic biological processes relevant to health and disease

Invito a presentare proposte

FP7-HEALTH-2009-two-stage
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

FUNDACIO CENTRE DE REGULACIO GENOMICA

Indirizzo

Carrer Doctor Aiguader 88
08003 Barcelona
Spagna

Tipo di attività

Research Organisations

Contatto amministrativo

Michela Bertero (Dr.)

Collegamenti

Contributo UE

€ 1 528 837

Partecipanti (13)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germania

Contributo UE

€ 1 034 185

Indirizzo

Hofgartenstrasse 8
80539 Munchen

Tipo di attività

Research Organisations

Contatto amministrativo

Birgit Gieding (Ms.)

Collegamenti

MEDICAL RESEARCH COUNCIL

United Kingdom

Contributo UE

€ 895 544

Indirizzo

20 Park Crescent
W1B 1AL London

Tipo di attività

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

Contatto amministrativo

John Wills (Mr.)

Collegamenti

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Francia

Contributo UE

€ 688 948

Indirizzo

Rue Michel Ange 3
75794 Paris

Tipo di attività

Research Organisations

Contatto amministrativo

Patrick Mounaud (Mr.)

Collegamenti

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Svizzera

Contributo UE

€ 1 345 851

Indirizzo

Raemistrasse 101
8092 Zuerich

Tipo di attività

Higher or Secondary Education Establishments

Contatto amministrativo

Rudolf Aebersold (Prof.)

Collegamenti

INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK

Polonia

Contributo UE

€ 643 110

Indirizzo

Pawinskiego 5a
02 106 Warszawa

Tipo di attività

Research Organisations

Contatto amministrativo

Agata Rogowska (Ms.)

Collegamenti

USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.

Cechia

Contributo UE

€ 485 521

Indirizzo

Flemingovo Nam. 542/2
16610 Praha 6

Tipo di attività

Research Organisations

Contatto amministrativo

Renata Sroglova (Ms.)

Collegamenti

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germania

Contributo UE

€ 1 308 514

Indirizzo

Meyerhofstrasse 1
69117 Heidelberg

Tipo di attività

Research Organisations

Contatto amministrativo

Ivanka Araujo (Ms.)

Collegamenti

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO

Italia

Contributo UE

€ 369 600

Indirizzo

Duomo 6
13100 Vercelli

Tipo di attività

Higher or Secondary Education Establishments

Contatto amministrativo

Carlo Muzio (Dr.)

Collegamenti

OMNIA MOLECULAR S.L.

Spagna

Contributo UE

€ 460 000

Indirizzo

Calle Josep Samitier - Parc Cientific De Barcelona 1-5
08028 Barcelona

Tipo di attività

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Contatto amministrativo

Maurici Torra Juanola (Mr.)

Collegamenti

LIONEX GMBH

Germania

Contributo UE

€ 479 240

Indirizzo

Salzdahlumer Strasse 196
38126 Braunschweig

Tipo di attività

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Contatto amministrativo

Mahavir Singh (Prof.)

Collegamenti

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germania

Contributo UE

€ 467 100

Indirizzo

Unter Den Linden 6
10117 Berlin

Tipo di attività

Higher or Secondary Education Establishments

Contatto amministrativo

Brigitte Lehmann (Dr.)

Collegamenti

WAGENINGEN UNIVERSITY

Paesi Bassi

Contributo UE

€ 748 151

Indirizzo

Droevendaalsesteeg 4
6708 PB Wageningen

Tipo di attività

Higher or Secondary Education Establishments

Contatto amministrativo

Jos Teunissen

Collegamenti

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgio

Contributo UE

€ 108 000

Indirizzo

Oude Markt 13
3000 Leuven

Tipo di attività

Higher or Secondary Education Establishments

Contatto amministrativo

Karolien Mariën (Mrs.)

Collegamenti