Objective Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of therapeutic approaches for myelin repair and neuroprotection constitutes the main objective of the LeukoTreat project. Indeed LDs constitute prototypic pathologies to tackle myelin formation/destruction issues as well as glial cells dysfunctions in neurodegeneration. The global aim is to promote the development of therapeutic strategies for the largest number of LD affected patients and further applications to more common white matter disorders and finally neurodegenerative diseases. For this purpose, the project will combine the expertise of (i) recognized European research teams in the field of White Matter diseases (COST Myelinet), (ii) high-technology SMEs, (iii) experts in medical ethics and (iv) LD patients and families associations. To develop efficient therapies, the LeukoTreat project is based on 5 complementary approaches consisting in: (i) collecting information on the epidemiology, the natural history, the genotype/phenotype correlation of LDs for at least 500 patients; (ii) validating/identifying biomarkers for therapeutic decisions/follow up to isolate new therapeutic targets; (iii) developing pharmacological strategies with the ultimate objective to launch at least 4 pharmacological clinical trials during 5 years following the project; (iv) developing innovative gene and cell therapies with the ultimate objective to launch at least 3 clinical trials during the next 5 years; (v) tackling ethical impacts of the proposed therapeutic challenges by integrating the participation of patients driven by a well-experienced research team strongly skilled in ethics Fields of science medical and health sciencesbasic medicineneurologymedical and health scienceshealth sciencesmedical ethics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.4.4-1 - Rare neurological diseases Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITE D'AUVERGNE CLERMONT-FERRAND 1 Address Boulevard francois mitterand 49 63001 Clermont-ferrand France See on map Activity type Higher or Secondary Education Establishments Administrative Contact Isabelle Rhit Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 796 258,60 Participants (24) Sort alphabetically Sort by EU Contribution Expand all Collapse all OSPEDALE PEDIATRICO BAMBINO GESU Italy EU contribution € 84 612,00 Address Piazza sant onofrio 4 00165 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Enrico Bertini (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO GIANNINA GASLINI Italy EU contribution € 100 300,00 Address Via gerolamo gaslini 5 16147 Genova See on map Region Nord-Ovest Liguria Genova Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Maria Gabriella Marinari Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATSKLINIKUM BONN Germany EU contribution € 352 480,00 Address Venusberg-campus 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Gieselmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 671 624,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Patrick Aubourg (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Soluscience SA France EU contribution € 300 800,00 Address Biopole clermont-limagne 63360 Saint-beauzire See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Yann Dantal (Mr.) Links Contact the organisation Opens in new window THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 359 380,00 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Spain EU contribution € 376 282,01 Address Avenida gran via hospitalet 199-203 08908 L'hospitalet de llobregat See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Victoria Cochrane (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 401 758,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Klaus-Armin Nave (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 337 888,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Johannes Berger (Prof.) Links Contact the organisation Opens in new window Website Opens in new window TROPHOS SA France EU contribution € 84 714,80 Address Parc scientifique luminy case 931 13288 Marseille cedex 9 See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Julien Veys (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UCL Elizabeth Garrett Anderson Institute for Women’s Health United Kingdom EU contribution € 93 825,76 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution € 388 600,00 Address Via olgettina 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Mario Valsecchi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 254 800,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Ronald Wanders (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Université Paris Descartes France EU contribution € 237 840,00 Address Rue de l'ecole de médecine 75270 cedex 06 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Grégoire Moutel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FRANCE EUROPE INNOVATION SAS France EU contribution € 277 119,00 Address 235 rue du faubourg saint honore 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olivier Degrand (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ASSOCIATION EUROPEENNE CONTRE LES LEUCODYSTROPHIES France EU contribution € 51 164,80 Address Rue mi-les-vignes 2 54520 Laxou See on map Activity type Other Administrative Contact Guy Alba (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 89 886,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Keith Cann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Université Paris Diderot-Paris 7 France EU contribution € 107 304,00 Address Rue thomas mann F-75205 / 13 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Muriel Maurice (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Italy EU contribution € 52 361,91 Address Via giovanni celoria 11 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Francesca Grechi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Participation ended Germany EU contribution € 0,00 Address Langenbeckstrasse 1 55131 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Matthias Klugmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany EU contribution € 112 920,34 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Alfried Kohlschütter (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 215 519,78 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Ingeborg Krägeloh-Mann (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF NEW SOUTH WALES Australia EU contribution € 207 287,00 Address Anzac parade 2052 Sydney See on map Activity type Higher or Secondary Education Establishments Administrative Contact Deirdre Mckay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE CENTRO SAN RAFFAELE Italy EU contribution € 23 400,00 Address Via olgettina 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maria Rosa Pedrazzi (Dr.) Links 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