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Discovery and preclinical development of new generation tuberculosis vaccines

Objective

With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current control measures the Millennium Development Goals (MDGs) set for 2015 may be achieved, reaching these would still leave a million people per year dying from TB. Much more effective measures, particularly more effective vaccines will be essential to reach the target of eliminating TB in 2050. Two successive FP5 and FP6 funded projects, Tuberculosis (TB) Vaccine Cluster (2000-2003) and TBVAC (2004-2008), have in the recent decade made significant contributions to the global TB vaccine pipeline, with four vaccines (out of nine globally) being advanced to clinical stages. Both projects strongly contributed to the strengthening and integration of expertise and led to a European focus of excellence that is unique in the area of TB vaccine development. In order to sustain and accelerate the TB vaccine developments and unique integrated excellence of TBVAC, a specific legal entity was created named TuBerculosis Vaccine Initiative (TBVI). The NEWTBVAC proposal is the FP7 successor of TBVAC, and will be coordinated by TBVI. The proposal has the following objectives : 1) To sustain and innovate the current European pipeline with new vaccine discoveries and advance promising candidates to clinical stages; 2) To design new, second generation vaccines based new prime-boost strategies and/or new (combinations of) promising subunit vaccines, that will impact on reduction of disease in exposed individuals; 3) To sustain and innovate discovery, evaluation and testing of new biomarkers, that will be critically important for future monitoring of clinical trials.

Field of science

  • /medical and health sciences/health sciences/infectious disease
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Address
Runderweg 6
8219 PH Lelystad
Netherlands
Activity type
Other
EU contribution
€ 1 052 419
Administrative Contact
Jelle Thole (Dr.)

Participants (34)

STATENS SERUM INSTITUT
Denmark
EU contribution
€ 815 000
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Administrative Contact
Stine Skipper (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 200 000
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefan Stevanovic (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 425 800
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 573 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tom Ottenhoff (Prof.)
INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE
Belgium
EU contribution
€ 199 800
Address
Rue Juliette Wytsman 14
1050 Bruxelles
Activity type
Research Organisations
Administrative Contact
Kris Huygen (Dr.)
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
EU contribution
€ 150 000
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pascal Mettens (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 497 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Martine Richard-Viard (Dr.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 188 000
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gennaro De Libero (Prof.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 167 100
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 542 000
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire-Anne Siegrist (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 626 575
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helen Mcshane (Dr.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 185 000
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
ASTON UNIVERSITY
United Kingdom
EU contribution
€ 185 000
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Perrie (Prof.)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 379 500
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Dr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 317 000
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francoise Mascart (Prof.)
INSTITUT PASTEUR
France
EU contribution
€ 586 000
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
INSTITUT PASTEUR KOREA
South Korea
Address
Hawolgok Dong, Seongbuk Gu 39-1
136 791 Seoul
Activity type
Research Organisations
Administrative Contact
Ewann Fanny (Dr.)
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 430 143
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oscar López Lorente (Dr.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 794 000
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Gieding (Ms.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 299 600
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Erik C. Boettger (Prof.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 200 000
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giorgio Bressan (Prof.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Stephen Kidner (Mr.)
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Netherlands
EU contribution
€ 778 000
Address
Lange Kleiweg 161
2288 GJ Rijswijk Zh
Activity type
Research Organisations
Administrative Contact
Frank Verreck (Dr.)
YONSEI UNIVERSITY
South Korea
Address
50 Yonsei Ro Seodaemun Gu
120 749 Seoul
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sang-Nae Cho (Dr.)
INTERNATIONAL VACCINE INSTITUTE
South Korea
Address
San 4-8 Bongcheon-7 Dong, Kwanak Gu
151919 Seoul
Activity type
Research Organisations
Administrative Contact
Michael Goon (Mr.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 145 000
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Norbert Stockhofe (Dr.)
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 244 366
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Administrative Contact
Pere-Joan Cardona (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 524 000
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jana Sabinovska (Ms.)
UNIVERSITA DEGLI STUDI DI PALERMO
Italy
EU contribution
€ 143 000
Address
Piazza Marina 61
90133 Palermo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Dieli (Prof.)
FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
EU contribution
€ 141 948
Address
Via Vincenzo Vela 6
6500 Bellinzona
Activity type
Research Organisations
Administrative Contact
Giorgio Noseda (Prof.)
PX'Therapeutics
France
EU contribution
€ 50 000
Address
15, Rue Des Martyrs
38027 Grenoble
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Mouz (Dr.)
MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT
Netherlands
EU contribution
€ 27 499
Address
Parnassusplein 5
2500 EJ Den Haag
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Erik P.J. Popping (Mr.)
VAKZINE PROJEKT MANAGEMENT GMBH
Germany
EU contribution
€ 100 000
Address
Mellendorfer Strasse 9
30625 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Inge Jacobi (Ms.)
Department of Health
United Kingdom
EU contribution
€ 1 029 980
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Cathy Rowe Rowe (Ms.)