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European Project on Mendelian Forms of Parkinson’s Disease

Objective

The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years it has become increasingly clear that progress in the understanding of the molecular basis of PD, the second most common neurodegenerative disorder, and hence the chance to develop effective disease-modifying treatments, will most likely be brought about by focusing on the rare variants of the disease with known genetic defects. The groups forming the MEFOPA-consortium will therefore analyze the molecular pathways underlying inherited forms of PD with autosomal-dominant and autosomal-recessive inheritance in an integrative way, using cellular and animal models and cutting-edge technology. These two subprojects will provide targets for novel, disease-modifying treatment strategies. In a third subproject, a European registry and biobank for patients with rare Mendelian forms of PD will be established. Body fluids will be collected and systematically analyzed by unbiased proteomic techniques as well as by focussed analysis of candidate proteins, and ex vivo cellular models will be generated, in order to allow validation of disease-related alterations detected in the models analyzed in subprojects 1 and 2. Through this integrated, translational approach combining basic and clinical research groups, the project aims to achieve measurable progress in defining the relevant targets and readouts for disease-modifying therapies and will set the stage for rationally designed drug trials in carefully selected groups of patients and even presymptomatic mutation carriers.

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Address
Geschwister-scholl-platz
72074 Tuebingen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 761 498
Administrative Contact
Holm Graessner (Dr.)

Participants (22)

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 216 000
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
Administrative Contact
Raptis Dimitris (Mr.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 352 800
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Deniz Kirik (Prof.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 324 000
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lone R. Larsen (Ms.)
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
EU contribution
€ 285 090
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Activity type
Research Organisations
Administrative Contact
Margarida Pinto Gago (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 360 000
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 288 000
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivo Wildhaber (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 268 800
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Olga Corti (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 330 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 288 316
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joanne Watson (Ms.)
TROPHOS SA
France
EU contribution
€ 362 364
Address
Parc Scientifique Luminy Case 931
13288 Marseille Cedex 9
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Julien Veys (Mr.)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 49 800
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Efi Kafentzi (Ms.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 42 000
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Emili Bargallo (Mr.)
FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA
Italy
EU contribution
€ 97 800
Address
Viale Cappuccini Sc
71013 San Giovanni Rotondo Fg
Activity type
Research Organisations
Administrative Contact
Giovanni Piano (Mr.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 114 000
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Madlen Kayserling (Ms.)
FUNDACION DE ESTUDIOS NEUROLOGICOS ILUNDAIN
Spain
EU contribution
€ 42 000
Address
Paseo De Francia 12
20001 San Sebastian
Activity type
Research Organisations
Administrative Contact
Marti Masso Jose Felix (Prof.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 2 400
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Benjamin Bereznai (Dr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nelom Kenneth (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health

Participation ended

United Kingdom
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 30 600
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geir Ketil Røste (Dr.)
UNITED ARAB EMIRATES UNIVERSITY
United Arab Emirates
Address
United Arab Emirates University
Al Ain
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Omar El-Agnaf (Prof.)
ISTANBUL UNIVERSITESI
Turkey
EU contribution
€ 25 000
Address
Istanbul Universitesi Center Campus Beyazit Eminonu
34452 Istanbul
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Osman Remzi Kuecuekoemeroglu
STICHTING VU
Netherlands
EU contribution
€ 519 000
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Kops (Dr.)