Objective The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years it has become increasingly clear that progress in the understanding of the molecular basis of PD, the second most common neurodegenerative disorder, and hence the chance to develop effective disease-modifying treatments, will most likely be brought about by focusing on the rare variants of the disease with known genetic defects. The groups forming the MEFOPA-consortium will therefore analyze the molecular pathways underlying inherited forms of PD with autosomal-dominant and autosomal-recessive inheritance in an integrative way, using cellular and animal models and cutting-edge technology. These two subprojects will provide targets for novel, disease-modifying treatment strategies. In a third subproject, a European registry and biobank for patients with rare Mendelian forms of PD will be established. Body fluids will be collected and systematically analyzed by unbiased proteomic techniques as well as by focussed analysis of candidate proteins, and ex vivo cellular models will be generated, in order to allow validation of disease-related alterations detected in the models analyzed in subprojects 1 and 2. Through this integrated, translational approach combining basic and clinical research groups, the project aims to achieve measurable progress in defining the relevant targets and readouts for disease-modifying therapies and will set the stage for rationally designed drug trials in carefully selected groups of patients and even presymptomatic mutation carriers. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.4.4-1 - Rare neurological diseases Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator EBERHARD KARLS UNIVERSITAET TUEBINGEN Address Geschwister-scholl-platz 72074 Tuebingen Germany See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (22) Sort alphabetically Sort by EU Contribution Expand all Collapse all IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 216 000,00 Address Soranou efesiou 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MAX IV Laboratory, Lund University Sweden EU contribution € 352 800,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data AARHUS UNIVERSITET Denmark EU contribution € 324 000,00 Address Nordre ringgade 1 8000 Aarhus c See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Portugal EU contribution € 285 090,00 Address Avenida prof egas moniz 1649 028 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 360 000,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NOVARTIS PHARMA AG Switzerland EU contribution € 288 000,00 Address Lichtstrasse 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 268 800,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 330 000,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF SHEFFIELD United Kingdom EU contribution € 288 316,00 Address Firth court western bank S10 2TN Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TROPHOS SA France EU contribution € 362 364,00 Address Parc scientifique luminy case 931 13288 Marseille cedex 9 See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece EU contribution € 49 800,00 Address 6 christou lada str 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 42 000,00 Address Carrer rossello 149 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA Italy EU contribution € 97 800,00 Address Viale cappuccini sc 71013 San giovanni rotondo fg See on map Region Sud Puglia Foggia Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET zu LUEBECK Germany EU contribution € 114 000,00 Address Ratzeburger allee 160 23562 Lubeck See on map Region Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FUNDACION DE ESTUDIOS NEUROLOGICOS ILUNDAIN Spain EU contribution € 42 000,00 Address Paseo de francia 12 20001 San sebastian See on map Activity type Research Organisations Links Contact the organisation Opens in new window Other funding No data SEMMELWEIS EGYETEM Hungary EU contribution € 2 400,00 Address Ulloi utca 26 1085 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Netherlands EU contribution € 0,00 Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UCL Elizabeth Garrett Anderson Institute for Women’s Health Participation ended United Kingdom EU contribution € 0,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data OSLO UNIVERSITETSSYKEHUS HF Norway EU contribution € 30 600,00 Address Kirkeveien 166 tarnbygget 0450 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNITED ARAB EMIRATES UNIVERSITY United Arab Emirates EU contribution € 0,00 Address United arab emirates university Al ain See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ISTANBUL UNIVERSITESI Türkiye EU contribution € 25 000,00 Address Istanbul universitesi center campus beyazit eminonu 34452 Istanbul See on map Region İstanbul İstanbul İstanbul Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data STICHTING VU Netherlands EU contribution € 519 000,00 Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data